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#genes

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The eukaryotic cell emerged as an evolutionary algorithmic phase transition / Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer proteins / Evolvement of the eukaryotic cell is the most significant increase in complexity in the history of life's evolution on Earth 👉 press.uni-mainz.de/eukaryotic-

A new study revealed that #caffeine impacts your thinking skills is not just about how much #coffee you drink, but also about your #genes. Researchers discovered people with genes for fast caffeine processing performed differently on cognitive tests depending on their caffeine consumption levels, particularly in tasks involving emotion recognition and complex thinking. Suggests #genetic makeup plays a significant role in how we respond to caffeine’s effects on brainpower.
journals.sagepub.com/doi/10.11

My day job is all about #genes, so I applaud the #genomic revolution in #paleontology and #evolutionary #biology. But #evolution really is more than a shift in #allele frequencies over time. It's also change in the #phenotypes those alleles produce, and their #interaction with the world around them. 🧪🖥🧬🦖

cambridge.org/core/journals/pa

So I'm equally excited about the #quantitative revolution in describing and cataloguing #traits which until recently could only be analyzed #qualitatively. There's a whole new window opening into the history of life.

Cambridge CoreMorphological evolution in a time of phenomics | Paleobiology | Cambridge CoreMorphological evolution in a time of phenomics

**Biological Constraint Engine**

Validates generated sequences against biological feasibility rules

Predicts #protein folding, metabolic interactions, and cellular dynamics
(Again this is something #AI is already good at)

Ensures synthetic organisms would be thermodynamically viable

**Simulation Environment**

Virtual cell environment to test synthetic genomes before physical synthesis.
(We have done this a while ago - pre AI)

Models interactions between #genes, #proteins, and environment

5/6

25 #genomes & 62 transcriptomes of ladybird beetles 🐞 - evolution of chemosensory, digestive, detoxifying, & immune #genes associated with dietary shifts 🥩<=>🥗 bmcbiol.biomedcentral.com/arti #biodiversity #genomics #evolution

BioMed CentralMolecular evolution of dietary shifts in ladybird beetles (Coleoptera: Coccinellidae): from fungivory to carnivory and herbivory - BMC BiologyBackground Dietary shifts are major evolutionary steps that shape ecological niches and biodiversity. The beetle family Coccinellidae, commonly known as ladybirds, first transitioned from a fungivorous to an insectivorous and subsequently a plant diet. However, the molecular basis of this dietary diversification remained unexplored. Results We investigated the molecular evolution of dietary shifts in ladybirds, focusing on the transitions from fungivory to carnivory (Coccinellidae) and from carnivory to herbivory (Epilachnini), by comparing 25 genomes and 62 transcriptomes of beetles. Our analysis shows that chemosensory gene families have undergone significant expansions at both nodes of diet change and were differentially expressed in feeding experiments, suggesting that they may be related to foraging. We found expansions of digestive and detoxifying gene families and losses of chitin-related digestive genes in the herbivorous ladybirds, and absence of most plant cell wall-degrading enzymes in the ladybirds dating from the transition to carnivory, likely indicating the effect of different digestion requirements on the gene repertoire. Immunity effector genes tend to emerge or have specific amino acid sequence compositions in carnivorous ladybirds and are downregulated under suboptimal dietary treatments, suggesting a potential function of these genes related to microbial symbionts in the sternorrhynchan prey. Conclusions Our study provides a comprehensive comparative genomic analysis to address evolution of chemosensory, digestive, detoxifying, and immune genes associated with dietary shifts in ladybirds. Ladybirds can be considered a ubiquitous example of dietary shifts in insects, and thus a promising model system for evolutionary and applied biology.

University of Southern California: Gene Ontology Consortium releases comprehensive resource describing functions of more than 20,000 human genes. “For the first time, researchers from the Keck School of Medicine of USC, the Swiss Institute of Bioinformatics and other institutions used large-scale evolutionary modeling to integrate data on human genes with genetic data collected from other […]

https://rbfirehose.com/2025/02/28/university-of-southern-california-gene-ontology-consortium-releases-comprehensive-resource-describing-functions-of-more-than-20000-human-genes/

ResearchBuzz: Firehose | Individual posts from ResearchBuzz · University of Southern California: Gene Ontology Consortium releases comprehensive resource describing functions of more than 20,000 human genes | ResearchBuzz: Firehose
More from ResearchBuzz: Firehose

Lifestyle & #environmental factors affect #health & aging more than our #genes (19/02/25. University of Oxford) sciencedaily.com/releases/2025

My view: Whilst the researchers offer the generic "we urgently need bold action from Government", what will undoubtedly reduce the risk factors across society, is to increase human general intelligence. For people to understand the risk factors of smoking & air pollution for example, a person has to be scientifically literate (intelligent enough)