Caspases have well known roles in #apoptosis, but roles in other cellular processes are emerging... This study shows that #caspase -3 & -7 promote cytoprotective #autophagy in response to non-lethal stress by modulating PARP1 activity in #BreastCancer cells #plosbiology https://plos.io/41xfLVm
I'm extracting DNA from the legs of spiders which were euthanized by freezing in a household freezer. In almost every spider, the DNA shows a banding pattern associated with apoptosis. Why would there be so much programed cell death in the legs of spiders? Had it already happened naturally? Was it induced during the freezing process? I do not see this happening in other organisms using the same extraction procedure.
Each lane is DNA extracted from a different spider.
For #epithelial tissue homeostasis, cell elimination & proliferation must balance. @DaikiUmetsu &co show that faster cell removal is associated with switch from isolated to clustered #apoptosis, induced by 
#endocytosis & EGFR signaling #PLOSBiology https://plos.io/403rQ3Y
What are the effects of #centrosome amplification in #cancer? @basto_lab &co show that extra centrosomes prime #OvarianCancer cells for #apoptosis, acting in synergy with #chemotherapy to induce cell death, correlating with improved survival #PLOSBiology https://plos.io/4dbmpD7
Researchers examine #protein arrangement in #cell_membrane that triggers programmed cell death
#apoptosis #CD95_receptor #signalling #image_spectroscopy #microscopy
https://phys.org/news/2024-09-protein-cell-membrane-triggers-death.html
How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c
~60% of germ cells in #Celegans hermaphrodites are eliminated in meiotic prophase to maintain tissue homeostasis, but how? This study shows that size of meiotic #GermCells is reduced by apical #actomyosin constriction, leading to #apoptosis #PLOSBiology https://plos.io/4g4hpTE
How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology https://plos.io/4dduEiq
A new star is born in the cilia world and cell death galaxy: Emilia Kieckhöfer brilliantly defended her PhD today! Congratulations!!! 
#cilia #necroptosis #bbs #raredisease #ciliopathies #celldeath #apoptosis #kidney #cysts #Nphp #Zilien
Just Published
Melatonin and Cancer: New Insights
BAK & BAX execute #apoptosis by increasing MOM permeability, regulated by #mitochondrial porin VDAC2. @theczabs @DewsonGrant &co characterize the BAK:VDAC2 interaction and show it can be targeted to promote/inhibit apoptosis @WEHI_research #PLOSBiology https://plos.io/4b0EqDY
#Marijuana Extract Can Kill #Melanoma Cells, New Study Reveals Possible Treatment For #SkinCancer
Story by Nina Zdinjak
February 8, 2024
"A new study indicates #cannabis has the potential to treat melanoma, a skin cancer beginning in the melanocyte cells, which make the pigment that gives skin its color.
"Melanoma typically results from over-exposure to the sun. While skin cancer is one of the most common cancers in the United States, melanoma accounts for only about 1%, yet causes a large majority of skin cancer deaths, according to the American Cancer Society.
"New research published in a peer-reviewed Cell Journal conducted by scientists from Charles Darwin University (CDU) and RMIT University offers hope for the creation of a natural treatment for melanoma.
"The study, part of a Ph.D. project by RMIT's Dr. Ava Bachari, showed that a specific cannabis extract (#PHEX66) from the #CannabisSativa plant binds to receptor sites on particular melanoma cells, controlling its growth at two key phases and increasing the amount of damage to these cells.
"Dr. Nazim Nassar, the study co-author and CDU pharmaceutical lecturer said this damage practically tricks cells into killing itself, writes Mirage News. This inhibitory effect arises from interactions with #CB1 and #CB2 receptors, the paper reads.
"'The damage to the melanoma cell prevents it from dividing into new cells, and instead begins a programmed cell death, also known as #apoptosis,' Dr. Nassar said. 'This is a growing area of important research because we need to understand cannabis extracts as much as possible, especially their potential to function as anticancer agents. If we know how they react to cancer cells, particularly in the cause of cell death, we can refine treatment techniques to be more specific, responsive and effective'.
"According to Nassar, who specializes in cancer cell biology, pharmacology and drug delivery systems, the next step should be to create a targeted delivery system for the melanoma cells in preparation for pre-clinical trials.
"'Clinical uses of cannabis extracts include treatment for anxiety, cancer-related symptoms, epilepsy, and chronic pain. Intensive research into its potential for killing melanoma cells is only the start as we investigate how this knowledge can be applied to treating different types of cancers,' Nassar said.
"Professor Nitin Mantir, lead author and RMIT biotechnologist, said there needs to be a thorough follow-up to assess the long-term efficiency and safety of the PHEC-66 extract.
"'The subsequent stage involves animal studies or pre-clinical trials to validate and further explore the efficacy of cannabinoid PHEC-66 in treating melanoma and other cancers,' Mantri said.
"Both authors stressed the need for support and sponsorship to eventually qualify PHEC-66 as a registered medicine."
How do differentiating cells communicate with progenitors to ensure precise control of organ size? Study of #Drosophila eyes shows that BMP molecule Dpp mediates this feedback by adjusting the rate of progenitor #apoptosis @fcasfer @omeuxeito #PLOSBiology https://plos.io/3uhh5xK
The multiple pathways that can trigger cell death in response to infection are not interchangeable and have specific outcomes in different cell types. #Salmonella #Apoptosis https://elifesciences.org/digests/89210/revealing-cell-death-differences?utm_source=mastodon&utm_medium=social&utm_campaign=organic
A user on #Pubpeer flagged the 2009 paper published in #Nature for image issues - the same image was copy-pasted as result of different essays.
When this happens, fraudsters usually claims honest error, but in this case, the conclusions have been proven false: in #Alzheimer's disease, APP - the precursor of amyloid beta - does not bind in the way suggested to DR6 - a receptor that induces neuronal #Apoptosis- and everything in that paper is a lie.
Sedanolide Activates KEAP1–NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death. https://doi.org/10.3390/ijms242216532 #Sedanolide #Are #Nrf2 #OxidativeStress #Apoptosis
My colleagues recently published a paper on #apoptosis in the #drosophila dorsal #epidermis. They have shown that two factors can predict #cell #extrusion and apoptosis. Cell size sensed by #hippo and relative cell size (compared to neighbors) sensed by #notch
https://www.cell.com/current-biology/fulltext/S0960-9822(23)01298-8
Highlight: Unlocking the Ancient Origins of Cell Death
https://doi.org/10.1093/gbe/evad172
"They propose that early protoeukaryotes were predators, relying on bacterial prey. These bacteria, in response to predation, produced toxins as a defense mechanism. Over time, these bacteria were domesticated to serve as mitochondria within eukaryotic cells, and their toxins evolved into apoptotic factors. "
12-OCT-2023
Programmed cell death may be 1.8 billion years old
https://www.eurekalert.org/news-releases/1004524
#science #evolution #apoptosis
