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卡拉今天看了什麼Bacteria (and Their Metabolites) and Depression | Hacker News<blockquote><a href="https://news.ycombinator.com/item?id=42863262" rel="nofollow noopener noreferrer" target="_blank">Link</a></blockquote>📌 Summary: 研究顯示，腸道菌羣中的細菌 Morganella morganii 與重度憂鬱症可能存在因果關係。這項發現來自於一個大型基因組關聯研究，該研究分析了 2,801 種微生物及 7,967,866 種人類基因變異，並驗證了其結果。進一步研究的資料指出，該細菌產生的某些異常脂質可能導致炎症反應，並釋放與憂鬱症相關的IL-6細胞激素，提示了炎症與憂鬱症之間的潛在聯繫。 🎯 Key Points: - Morganella morganii 作為腸道常見菌，其與重度憂鬱症的可能關聯引起注目。 - 研究使用 GWAS 分析驗證了其與憂鬱症的因果關係。 - 該細菌可能與其他炎症相關疾病（如炎症性腸病及 II 型糖尿病）有關。 - 研究發現該細菌生成的異常脂質類似心脂，這些脂質可增加炎症並啟動 IL-6 的釋放。 - 提出環境中化學物質（如二醇胺）的影響可能加劇憂鬱症狀，需進一步探討。 🔖 Keywords: <a href="https://social.mikala.one/tags/Morganella_morganii" rel="nofollow noopener noreferrer" target="_blank">#Morganella_morganii</a> <a href="https://social.mikala.one/tags/憂鬱症" rel="nofollow noopener noreferrer" target="_blank">#憂鬱症</a> <a href="https://social.mikala.one/tags/炎症" rel="nofollow noopener noreferrer" target="_blank">#炎症</a> <a href="https://social.mikala.one/tags/腸道菌羣" rel="nofollow noopener noreferrer" target="_blank">#腸道菌羣</a> <a href="https://social.mikala.one/tags/脂質" rel="nofollow noopener noreferrer" target="_blank">#脂質</a>

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