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Johannes W. Dietrich<a href="https://qoto.org/tags/Syndrome_T" class="mention hashtag" rel="nofollow noopener" target="_blank">#Syndrome_T</a>, i.e. persistent symptoms and reduced <a href="https://qoto.org/tags/QoL" class="mention hashtag" rel="nofollow noopener" target="_blank">#QoL</a> despite normal <a href="https://qoto.org/tags/TSH" class="mention hashtag" rel="nofollow noopener" target="_blank">#TSH</a> concentration, affects 10% of <a href="https://qoto.org/tags/hypothyroid" class="mention hashtag" rel="nofollow noopener" target="_blank">#hypothyroid</a> patients on <a href="https://qoto.org/tags/levothyroxine" class="mention hashtag" rel="nofollow noopener" target="_blank">#levothyroxine</a>. Careful, multimodal and personalised treatment can result in significantly improved outcomes.<a href="https://qoto.org/tags/hypothyroidism" class="mention hashtag" rel="nofollow noopener" target="_blank">#hypothyroidism</a> <a href="https://qoto.org/tags/thyroid" class="mention hashtag" rel="nofollow noopener" target="_blank">#thyroid</a> <a href="https://qoto.org/tags/SORSHOT" class="mention hashtag" rel="nofollow noopener" target="_blank">#SORSHOT</a><a href="https://doi.org/10.1007/978-981-96-3682-2_11" rel="nofollow noopener" target="_blank">https://doi.org/10.1007/978-981-96-3682-2_11</a>

SPINA TeamGrowing evidence supports a role of sensorimotor and autonomic <a href="https://fosstodon.org/tags/neuropathy" class="mention hashtag" rel="tag">#neuropathy</a> in <a href="https://fosstodon.org/tags/syndrome_T" class="mention hashtag" rel="tag">#syndrome_T</a> or <a href="https://fosstodon.org/tags/SORSHOT" class="mention hashtag" rel="tag">#SORSHOT</a>, i.e. reduced quality of life in treated <a href="https://fosstodon.org/tags/hypothyroidism" class="mention hashtag" rel="tag">#hypothyroidism</a>. <a href="https://fosstodon.org/tags/SPINA_GT" class="mention hashtag" rel="tag">#SPINA_GT</a> and <a href="https://fosstodon.org/tags/SPINA_GD" class="mention hashtag" rel="tag">#SPINA_GD</a> predict nerve function and depression.<a href="https://pubmed.ncbi.nlm.nih.gov/38811750/" target="_blank" rel="nofollow noopener" translate="no">https://pubmed.ncbi.nlm.nih.gov/38811750/</a><a href="https://doi.org/10.1038/s41598-024-63158-w" target="_blank" rel="nofollow noopener" translate="no">https://doi.org/10.1038/s41598-024-63158-w</a>

Johannes W. DietrichShould we, therefore, classify <a href="https://qoto.org/tags/syndrome_T" class="mention hashtag" rel="nofollow noopener" target="_blank">#syndrome_T</a> as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic <a href="https://qoto.org/tags/neuropathy" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuropathy</a> that depend on autoimmunity and <a href="https://qoto.org/tags/thyroid" class="mention hashtag" rel="nofollow noopener" target="_blank">#thyroid</a>'s secretory capacity (<a href="https://qoto.org/tags/SPINA_GT" class="mention hashtag" rel="nofollow noopener" target="_blank">#SPINA_GT</a>).

Johannes W. DietrichOur newest paper provides new insights into the conundrum of <a href="https://qoto.org/tags/syndrome_T" class="mention hashtag" rel="nofollow noopener" target="_blank">#syndrome_T</a> / <a href="https://qoto.org/tags/sorshot" class="mention hashtag" rel="nofollow noopener" target="_blank">#sorshot</a>. <a href="https://qoto.org/tags/Anxiety" class="mention hashtag" rel="nofollow noopener" target="_blank">#Anxiety</a> and <a href="https://qoto.org/tags/depression" class="mention hashtag" rel="nofollow noopener" target="_blank">#depression</a> are significantly more common in autoimmune <a href="https://qoto.org/tags/thyroiditis" class="mention hashtag" rel="nofollow noopener" target="_blank">#thyroiditis</a> compared to healthy controls.<a href="https://qoto.org/tags/thyroid" class="mention hashtag" rel="nofollow noopener" target="_blank">#thyroid</a> <a href="https://qoto.org/tags/qol" class="mention hashtag" rel="nofollow noopener" target="_blank">#qol</a><a href="https://doi.org/10.1038/s41598-024-63158-w" rel="nofollow noopener" target="_blank">https://doi.org/10.1038/s41598-024-63158-w</a>

Johannes W. DietrichDoes impaired transport of <a href="https://qoto.org/tags/thyroid" class="mention hashtag" rel="nofollow noopener" target="_blank">#thyroid</a> hormones into the central nervous system contribute to <a href="https://qoto.org/tags/syndrome_T" class="mention hashtag" rel="nofollow noopener" target="_blank">#syndrome_T</a> / <a href="https://qoto.org/tags/SORSHOT" class="mention hashtag" rel="nofollow noopener" target="_blank">#SORSHOT</a>? A recent study observed CSF/serum FT4 ratio to be associated with <a href="https://qoto.org/tags/QoL" class="mention hashtag" rel="nofollow noopener" target="_blank">#QoL</a> in treated <a href="https://qoto.org/tags/hypothyroidism" class="mention hashtag" rel="nofollow noopener" target="_blank">#hypothyroidism</a>. <a href="https://doi.org/10.1111/jne.13272" rel="nofollow noopener" target="_blank">https://doi.org/10.1111/jne.13272</a>

Johannes W. DietrichIs reduced quality of life in <a href="https://qoto.org/tags/hypothyroidism" class="mention hashtag" rel="nofollow noopener" target="_blank">#hypothyroidism</a> a psychological issue? A poster presented at <a href="https://qoto.org/tags/ECE2023" class="mention hashtag" rel="nofollow noopener" target="_blank">#ECE2023</a> suggests this. It is, however, impossible to prove causality in a case-control study. We need prospective studies to understand <a href="https://qoto.org/tags/syndrome_T" class="mention hashtag" rel="nofollow noopener" target="_blank">#syndrome_T</a> / <a href="https://qoto.org/tags/SORSHOT" class="mention hashtag" rel="nofollow noopener" target="_blank">#SORSHOT</a>. <a href="https://doi.org/10.1530/endoabs.90.P271" rel="nofollow noopener" target="_blank">https://doi.org/10.1530/endoabs.90.P271</a>

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