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Bret Mogilefsky📈📉📈😩For those struggling with their weight and related health problems: Below I wrote up a thread about my brief experience so far with being prescribed the GLP1-agonist drugs <a href="https://hachyderm.io/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a> (aka <a href="https://hachyderm.io/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a> / <a href="https://hachyderm.io/tags/Wegovy" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wegovy</a>) and <a href="https://hachyderm.io/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a> (aka <a href="https://hachyderm.io/tags/Mounjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mounjaro</a> / <a href="https://hachyderm.io/tags/Zepbound" class="mention hashtag" rel="nofollow noopener" target="_blank">#Zepbound</a>), and my struggle to get insurance coverage (boo <a href="https://hachyderm.io/tags/FEPBlue" class="mention hashtag" rel="nofollow noopener" target="_blank">#FEPBlue</a>! You suck!).🧪🥼I also talk light science about a related experimental drug called <a href="https://hachyderm.io/tags/bimagrumab" class="mention hashtag" rel="nofollow noopener" target="_blank">#bimagrumab</a> that I *might* be helping to test via a <a href="https://hachyderm.io/tags/ClinicalTrial" class="mention hashtag" rel="nofollow noopener" target="_blank">#ClinicalTrial</a>. It's pretty fascinating stuff! <a href="https://hachyderm.io/@mogul/114844234796648397" rel="nofollow noopener" translate="no" target="_blank">https://hachyderm.io/@mogul/114844234796648397</a>

Douglas Edwards :neurodiv:<a href="https://beige.party/@miffyhelen" class="u-url mention" rel="nofollow noopener" target="_blank">@miffyhelen</a> I'm type 2 diabetic AND an inpatient pharmacist. Ever since I started taking <a href="https://zeroes.ca/tags/incretin" class="mention hashtag" rel="nofollow noopener" target="_blank">#incretin</a> drugs — first <a href="https://zeroes.ca/tags/Bydureon" class="mention hashtag" rel="nofollow noopener" target="_blank">#Bydureon</a> (<a href="https://zeroes.ca/tags/exenatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#exenatide</a>), then <a href="https://zeroes.ca/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a> (<a href="https://zeroes.ca/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>), and most recently <a href="https://zeroes.ca/tags/Mounjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mounjaro</a> (<a href="https://zeroes.ca/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a>) — it has transformed my experience of exercise. Before, I never understood how anyone could enjoy exercise. I suspect another diabetes drug of a different class, good old <a href="https://zeroes.ca/tags/metformin" class="mention hashtag" rel="nofollow noopener" target="_blank">#metformin</a>, is helping too. <a href="https://zeroes.ca/tags/Mounjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mounjaro</a>, especially, has made a world of difference. If you're not diabetic, <a href="https://zeroes.ca/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a> is also available as a weight-loss drug under a different name (<a href="https://zeroes.ca/tags/Zepbound" class="mention hashtag" rel="nofollow noopener" target="_blank">#Zepbound</a>). And another <a href="https://zeroes.ca/tags/incretin" class="mention hashtag" rel="nofollow noopener" target="_blank">#incretin</a> drug, not approved yet, is on the horizon: <a href="https://zeroes.ca/tags/retatrutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#retatrutide</a>. From everything I've read about it, it should be the best of all.

Snark Week Global<a href="https://mstdn.social/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a> in het <a href="https://mstdn.social/tags/basispakket" class="mention hashtag" rel="nofollow noopener" target="_blank">#basispakket</a> gaat naar mijn inschatting ~10 miljard per jaar kosten.<a href="https://mstdn.social/tags/zorg" class="mention hashtag" rel="nofollow noopener" target="_blank">#zorg</a> <a href="https://mstdn.social/tags/gezondheid" class="mention hashtag" rel="nofollow noopener" target="_blank">#gezondheid</a> <a href="https://mstdn.social/tags/zorgverzekering" class="mention hashtag" rel="nofollow noopener" target="_blank">#zorgverzekering</a>

Christos Argyropoulos MD, PhDWe should talk about what hides under the clinical successes of <a href="https://med-mastodon.com/tags/glp1" class="mention hashtag" rel="nofollow noopener" target="_blank">#glp1</a> e.g. <a href="https://med-mastodon.com/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a> or <a href="https://med-mastodon.com/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>. A paper published in the last 6 months suggests that the benefits (at least as the <a href="https://med-mastodon.com/tags/kidneys" class="mention hashtag" rel="nofollow noopener" target="_blank">#kidneys</a>) are concerned are only partly (45%) explained by weight loss. What are we missing?

Christos Argyropoulos MD PhDWe should talk about what hides under the clinical successes of <a href="https://mastodon.social/tags/glp1" class="mention hashtag" rel="nofollow noopener" target="_blank">#glp1</a> e.g. <a href="https://mastodon.social/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a> or <a href="https://mastodon.social/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>. A paper published in the last 6 months suggests that the benefits (at least as the <a href="https://mastodon.social/tags/kidneys" class="mention hashtag" rel="nofollow noopener" target="_blank">#kidneys</a>) are concerned are only partly (45%) explained by weight loss. What are we missing?

Christos Argyropoulos MD, PhD, FASN 🇺🇸We should talk about what hides under the clinical successes of <a class="hashtag" rel="nofollow noopener" href="https://bsky.app/search?q=%23glp1" target="_blank">#glp1</a> e.g. <a class="hashtag" rel="nofollow noopener" href="https://bsky.app/search?q=%23tirzepatide" target="_blank">#tirzepatide</a> or <a class="hashtag" rel="nofollow noopener" href="https://bsky.app/search?q=%23semaglutide" target="_blank">#semaglutide</a>. A paper published in the last 6 months suggests that the benefits (at least as the <a class="hashtag" rel="nofollow noopener" href="https://bsky.app/search?q=%23kidneys" target="_blank">#kidneys</a>) are concerned are only partly (45%) explained by weight loss. What are we missing?

skry'"PRAC said it found that [blindness] is “a very rare side effect” of semaglutide, potentially affecting up to one in 10,000 people taking the drug. The EMA said that exposure to semaglutide in people with <a href="https://mastodon.social/tags/diabetes" class="mention hashtag" rel="nofollow noopener" target="_blank">#diabetes</a> is linked to a twofold increase in the risk of developing NAION compared with people not taking the medicine.'<a href="https://www.politico.eu/article/ozempic-has-very-rare-sight-loss-side-effect-eu-drugs-regulator-finds/" rel="nofollow noopener" translate="no" target="_blank">https://www.politico.eu/article/ozempic-has-very-rare-sight-loss-side-effect-eu-drugs-regulator-finds/</a> <a href="https://mastodon.social/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a> <a href="https://mastodon.social/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#medicine</a>

Yonhap Infomax NewsNovo Nordisk will lose patent protection for semaglutide in China next year, opening the market to up to 20 biosimilar and generic competitors amid intensifying competition. <a href="https://mastodon.social/tags/YonhapInfomax" class="mention hashtag" rel="nofollow noopener" target="_blank">#YonhapInfomax</a> <a href="https://mastodon.social/tags/NovoNordisk" class="mention hashtag" rel="nofollow noopener" target="_blank">#NovoNordisk</a> <a href="https://mastodon.social/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a> <a href="https://mastodon.social/tags/PatentExpiry" class="mention hashtag" rel="nofollow noopener" target="_blank">#PatentExpiry</a> <a href="https://mastodon.social/tags/ChinaPharmaceuticalMarket" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChinaPharmaceuticalMarket</a> <a href="https://mastodon.social/tags/GLP1Drugs" class="mention hashtag" rel="nofollow noopener" target="_blank">#GLP1Drugs</a> <a href="https://mastodon.social/tags/Economics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Economics</a> <a href="https://mastodon.social/tags/FinancialMarkets" class="mention hashtag" rel="nofollow noopener" target="_blank">#FinancialMarkets</a> <a href="https://mastodon.social/tags/Banking" class="mention hashtag" rel="nofollow noopener" target="_blank">#Banking</a> <a href="https://mastodon.social/tags/Securities" class="mention hashtag" rel="nofollow noopener" target="_blank">#Securities</a> <a href="https://mastodon.social/tags/Bonds" class="mention hashtag" rel="nofollow noopener" target="_blank">#Bonds</a> <a href="https://mastodon.social/tags/StockMarket" class="mention hashtag" rel="nofollow noopener" target="_blank">#StockMarket</a> <a href="https://en.infomaxai.com/news/articleView.html?idxno=65853" rel="nofollow noopener" translate="no" target="_blank">https://en.infomaxai.com/news/articleView.html?idxno=65853</a>

GeekooScientists find brain cells that cause weight loss—without nausea. This could lead to safer, smarter obesity drugs. <a href="https://mastodon.social/tags/BrainScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#BrainScience</a> <a href="https://mastodon.social/tags/ObesityTreatment" class="mention hashtag" rel="nofollow noopener" target="_blank">#ObesityTreatment</a> <a href="https://mastodon.social/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a><a href="https://geekoo.news/the-brain-cells-that-control-weight-loss-without-side-effects/" rel="nofollow noopener" translate="no" target="_blank">https://geekoo.news/the-brain-cells-that-control-weight-loss-without-side-effects/</a>

DrBob, Neurologist, 🧠MechanicUnique new drug for <a href="https://vmst.io/tags/Obesity" class="mention hashtag" rel="nofollow noopener" target="_blank">#Obesity</a>?BAM15, semaglutide, rosiglitazone, and pioglitazone in diet-induced obese mice The study compares <a href="https://vmst.io/tags/BAM15" class="mention hashtag" rel="nofollow noopener" target="_blank">#BAM15</a> with <a href="https://vmst.io/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a>, rosiglitazone, and pioglitazone in obese mice. BAM15 outperformed the others in reducing body weight, improving insulin sensitivity, enhancing glucose tolerance, and reducing liver fat and inflammation.Its unique mechanism—mitochondrial uncoupling—increases energy expenditure rather than altering insulin pathways.No major side effects were observed. Human research is needed. <a href="https://vmst.io/tags/wegovy" class="mention hashtag" rel="nofollow noopener" target="_blank">#wegovy</a> <a href="https://vmst.io/tags/ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#ozempic</a> <a href="https://vmst.io/tags/mounjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#mounjaro</a> <a href="https://vmst.io/tags/zepbound" class="mention hashtag" rel="nofollow noopener" target="_blank">#zepbound</a> <a href="https://www.sciencedirect.com/science/article/pii/S0925443923002740" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedirect.com/science/article/pii/S0925443923002740</a>

🦠Toxic Flange (Gurjeet)🔬⚱️🌚Holy shit, <a href="https://infosec.exchange/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a> is expensive in Canada , $505.59 for my first set of doses . Yay for insurance but still ..how much is it in the states?<a href="https://infosec.exchange/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a> <a href="https://infosec.exchange/tags/Wegovy" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wegovy</a>

Martin Michaelis (he/him)<a href="https://mastodonapp.uk/tags/Evidence" class="mention hashtag" rel="nofollow noopener" target="_blank">#Evidence</a> that <a href="https://mastodonapp.uk/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a> (<a href="https://mastodonapp.uk/tags/Munjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#Munjaro</a>) causes more pronounced <a href="https://mastodonapp.uk/tags/weightloss" class="mention hashtag" rel="nofollow noopener" target="_blank">#weightloss</a> than <a href="https://mastodonapp.uk/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a> (<a href="https://mastodonapp.uk/tags/Wegovy" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wegovy</a>, <a href="https://mastodonapp.uk/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a>, <a href="https://mastodonapp.uk/tags/Rybelsus" class="mention hashtag" rel="nofollow noopener" target="_blank">#Rybelsus</a>). Notably, the trial was funded by the pharma company behind tirzepatide.<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2416394" rel="nofollow noopener" translate="no" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa2416394</a>

OtherRynI've discovered that the primary contributor to nausea for me with Semaglutide is... Coffee. I'm gonna miss you, coffee. We'll be trying tea in the morning to see if it's caffeine-related or if it's the acidity of coffee.But removing coffee from the equation means that now when I do anything that works my core muscles, I don't feel like I need to hurl after five minutes.<a href="https://sunny.garden/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>

DrBob, Neurologist, 🧠MechanicNew Review and Meta-Analysis confirms weight gain with discontinuance of <a href="https://vmst.io/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a> and <a href="https://vmst.io/tags/Tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Tirzepatide</a> Discontinuing GLP1 medications led to a pooled overall mean weight regain of 9.69 kg (or about 22 lbs in patients prescribed semaglutide/tirzepatide. The proportion of weight regained was proportional to the amount originally lost.Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to <a href="https://vmst.io/tags/Obesity" class="mention hashtag" rel="nofollow noopener" target="_blank">#Obesity</a>.<a href="https://vmst.io/tags/wegovy" class="mention hashtag" rel="nofollow noopener" target="_blank">#wegovy</a> <a href="https://vmst.io/tags/ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#ozempic</a> <a href="https://vmst.io/tags/mounjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#mounjaro</a> <a href="https://vmst.io/tags/zepbound" class="mention hashtag" rel="nofollow noopener" target="_blank">#zepbound</a> <a href="https://onlinelibrary.wiley.com/doi/10.1111/obr.13929" rel="nofollow noopener" translate="no" target="_blank">https://onlinelibrary.wiley.com/doi/10.1111/obr.13929</a>

Martin Michaelis (he/him)GLP-1 receptor agonists may reduce the risk of haematological <a href="https://mastodonapp.uk/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancer</a> in patients with type 2 <a href="https://mastodonapp.uk/tags/diabetes" class="mention hashtag" rel="nofollow noopener" target="_blank">#diabetes</a>. <a href="https://mastodonapp.uk/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a> <a href="https://mastodonapp.uk/tags/liraglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#liraglutide</a> <a href="https://mastodonapp.uk/tags/tirzepatide" class="mention hashtag" rel="nofollow noopener" target="_blank">#tirzepatide</a> <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831083" rel="nofollow noopener" translate="no" target="_blank">https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831083</a>

OtherRynI just did three hours of gardening/outside chores and while I started a little high (170s), and I set an ease-off on my pump, I did not go hypo.I know for a fact that this would not have happened last year. I would have been pausing and having a capri sun every 30-45 minutes.I'm very pleased. And a little confused, but I'm gonna take the win.<a href="https://sunny.garden/tags/T1D" class="mention hashtag" rel="nofollow noopener" target="_blank">#T1D</a> <a href="https://sunny.garden/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>

Nick Byrd, Ph.D.If you lose 50 pounds (23 kg) after being significantly overweight for years, how praiseworthy are you?Praise varied by <a href="https://nerdculture.de/tags/weightLoss" class="mention hashtag" rel="nofollow noopener" target="_blank">#weightLoss</a> method: A. <a href="https://nerdculture.de/tags/diet" class="mention hashtag" rel="nofollow noopener" target="_blank">#diet</a> + <a href="https://nerdculture.de/tags/exercise" class="mention hashtag" rel="nofollow noopener" target="_blank">#exercise</a> B. <a href="https://nerdculture.de/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a> (e.g., <a href="https://nerdculture.de/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a>) C. A and BSo did perceived effort ...and identity?<a href="https://osf.io/preprints/psyarxiv/a7rqy" rel="nofollow noopener" translate="no" target="_blank">https://osf.io/preprints/psyarxiv/a7rqy</a> <a href="https://nerdculture.de/tags/xPhi" class="mention hashtag" rel="nofollow noopener" target="_blank">#xPhi</a>

kurtshAs someone actively on a GLP-1 as a diabetic, this explainer around the economics of these drugs is both fascinating & maddening. ✅ The Ozempocalypse Is Nigh - by Scott Alexander <a href="https://www.astralcodexten.com/p/the-ozempocalypse-is-nigh" rel="nofollow noopener" translate="no" target="_blank">https://www.astralcodexten.com/p/the-ozempocalypse-is-nigh</a> <a href="https://mastodon.social/tags/glp1" class="mention hashtag" rel="nofollow noopener" target="_blank">#glp1</a> <a href="https://mastodon.social/tags/ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#ozempic</a> <a href="https://mastodon.social/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>

DrBob, Neurologist, 🧠MechanicForget Psychedelics 😵‍💫Everyone’s Microdosing Ozempic Now 🤔“Shamoon has joined the wave of people who are taking limited amounts not of psychedelics — to which the microdosing trend usually applies — but of the diabetes drug <a href="https://vmst.io/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a> (<a href="https://vmst.io/tags/semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#semaglutide</a>), and other <a href="https://vmst.io/tags/GLP1" class="mention hashtag" rel="nofollow noopener" target="_blank">#GLP1</a> receptor agonists like <a href="https://vmst.io/tags/Mounjaro" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mounjaro</a>They are doing it not primarily for weight loss — the effect that has made Ozempic a Hollywood staple and a reliable awards-show punchline — but for the surprising and widely touted side benefits, particularly its anti-inflammatory properties”<a href="https://www.hollywoodreporter.com/lifestyle/lifestyle-news/microdosing-ozempic-weight-loss-health-gains-1236126989/" rel="nofollow noopener" translate="no" target="_blank">https://www.hollywoodreporter.com/lifestyle/lifestyle-news/microdosing-ozempic-weight-loss-health-gains-1236126989/</a>

Flipboard Science DeskA new study confirms that people using semaglutide for diabetes or weight loss have also reported experiencing a reduced desire for alcohol. <a href="https://flipboard.com/@ScienceAlert" class="u-url mention" rel="nofollow noopener" target="_blank">@ScienceAlert</a> reports: <a href="https://www.sciencealert.com/ozempic-reduces-desire-to-binge-alcohol-suggests-amazing-new-study" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencealert.com/ozempic-reduces-desire-to-binge-alcohol-suggests-amazing-new-study</a><a href="https://flipboard.social/tags/Ozempic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Ozempic</a> <a href="https://flipboard.social/tags/WeightLoss" class="mention hashtag" rel="nofollow noopener" target="_blank">#WeightLoss</a> <a href="https://flipboard.social/tags/Alcohol" class="mention hashtag" rel="nofollow noopener" target="_blank">#Alcohol</a> <a href="https://flipboard.social/tags/Semaglutide" class="mention hashtag" rel="nofollow noopener" target="_blank">#Semaglutide</a>

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