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Giuseppe Michieli<a href="https://mstdn.science/tags/Aminoacid" class="mention hashtag" rel="nofollow noopener" target="_blank">#Aminoacid</a> <a href="https://mstdn.science/tags/mutations" class="mention hashtag" rel="nofollow noopener" target="_blank">#mutations</a> <a href="https://mstdn.science/tags/PB1" class="mention hashtag" rel="nofollow noopener" target="_blank">#PB1</a>-V719M and <a href="https://mstdn.science/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a>-N444D combined with <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="nofollow noopener" target="_blank">#PB2</a>-627K contribute to the <a href="https://mstdn.science/tags/pathogenicity" class="mention hashtag" rel="nofollow noopener" target="_blank">#pathogenicity</a> of <a href="https://mstdn.science/tags/H7N9" class="mention hashtag" rel="nofollow noopener" target="_blank">#H7N9</a> in <a href="https://mstdn.science/tags/mice" class="mention hashtag" rel="nofollow noopener" target="_blank">#mice</a>, Vet Res.: <a href="https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6" rel="nofollow noopener" translate="no" target="_blank">https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6</a> Overall, this study revealed that <a href="https://mstdn.science/tags/virulence" class="mention hashtag" rel="nofollow noopener" target="_blank">#virulence</a> in H7N9 is a <a href="https://mstdn.science/tags/polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#polygenic</a> trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.

Daniel E. WeeksSTATGEN 2024 talk Polygenic risk score analysis for multiethnic populations Chris AmosPolygenic Risk Scores (PRS) * Inform re biological processes * Identify some at higher risk * Might motivate behavioral changePRS could inform when to start screening."measles plot instead of a manhattan plot" - has excessive false positives all over the genome.Lung cancer risk snp also is related to response to smoking cessation1/<a href="https://fediscience.org/tags/STATGEN2024" class="mention hashtag" rel="nofollow noopener" target="_blank">#STATGEN2024</a> <a href="https://fediscience.org/tags/Polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Polygenic</a> <a href="https://fediscience.org/tags/StatisticalGenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#StatisticalGenetics</a> <a href="https://fediscience.org/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a> <a href="https://fediscience.org/tags/PRS" class="mention hashtag" rel="nofollow noopener" target="_blank">#PRS</a>

MPI for Empirical Aesthetics<a href="https://social.mpdl.mpg.de/tags/Beethoven" class="mention hashtag" rel="nofollow noopener" target="_blank">#Beethoven</a>'s <a href="https://social.mpdl.mpg.de/tags/musicality" class="mention hashtag" rel="nofollow noopener" target="_blank">#musicality</a> put to the test: An international <a href="https://social.mpdl.mpg.de/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#research</a> team incl. <a href="https://mstdn.science/@mpi_nl" class="u-url mention" rel="nofollow noopener" target="_blank">@mpi_nl</a> and <a href="https://social.mpdl.mpg.de/@MPI_ae" class="u-url mention" rel="nofollow noopener" target="_blank">@MPI_ae</a> set out to analyze the composer’s <a href="https://social.mpdl.mpg.de/tags/genetic" class="mention hashtag" rel="nofollow noopener" target="_blank">#genetic</a> predisposition by calculating his <a href="https://social.mpdl.mpg.de/tags/polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#polygenic</a> score for <a href="https://social.mpdl.mpg.de/tags/beat" class="mention hashtag" rel="nofollow noopener" target="_blank">#beat</a> synchronization ability. Out now in <a href="https://mstdn.science/@CurrentBiology" class="u-url mention" rel="nofollow noopener" target="_blank">@CurrentBiology</a>: <a href="https://doi.org/10.1016/j.cub.2024.01.025" rel="nofollow noopener" translate="no" target="_blank">https://doi.org/10.1016/j.cub.2024.01.025</a>

Scientific FrontlineResearchers have developed statistical tools called <a href="https://mastodon.social/tags/polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#polygenic</a> risk scores (PRSs) that can estimate individuals’ risk for certain diseases with strong <a href="https://mastodon.social/tags/genetic" class="mention hashtag" rel="nofollow noopener" target="_blank">#genetic</a> components, such as <a href="https://mastodon.social/tags/heart" class="mention hashtag" rel="nofollow noopener" target="_blank">#heart</a> disease or <a href="https://mastodon.social/tags/diabetes" class="mention hashtag" rel="nofollow noopener" target="_blank">#diabetes</a>. <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2024/03/gen03192401.html" rel="nofollow noopener" translate="no" target="_blank">https://www.sflorg.com/2024/03/gen03192401.html</a>

Luke PembletonThis festive season 🎄 give the gift 🎁 of a <a href="https://genomic.social/tags/Bayesian" class="mention hashtag" rel="nofollow noopener" target="_blank">#Bayesian</a> model to a friend still trying to run a frequentist linkage mapping approach looking for significant associations 🧬🖥️<a href="https://genomic.social/tags/genomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#genomics</a> <a href="https://genomic.social/tags/QuantitativeGenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#QuantitativeGenetics</a> <a href="https://genomic.social/tags/polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#polygenic</a> <a href="https://genomic.social/tags/omnigenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#omnigenic</a>

Daniel E. Weeks"Polygenic risk scores performed poorly in population screening, individual risk prediction, and population risk stratification. Strong claims about the effect of polygenic risk scores on healthcare seem to be disproportionate to their performance."Hingorani et al. Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog. BMJ Medicine. 2023 Oct 1;2(1). DOI: <a href="https://doi.org/10.1136/bmjmed-2023-000554" rel="nofollow noopener" target="_blank">https://doi.org/10.1136/bmjmed-2023-000554</a> <a href="https://fediscience.org/tags/genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#genetics</a> <a href="https://fediscience.org/tags/polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#polygenic</a>

Nicolas BierneA polygenic explanation for Haldane’s rule in butterflies Xiong et al. (Jim Mallet's team) <a href="https://ecoevo.social/tags/PopGen" class="mention hashtag" rel="nofollow noopener" target="_blank">#PopGen</a> <a href="https://ecoevo.social/tags/Hybridization" class="mention hashtag" rel="nofollow noopener" target="_blank">#Hybridization</a> <a href="https://ecoevo.social/tags/Polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#Polygenic</a> "numerous small-effect factors on a single chromosome can appear as spurious large-effect loci. This mapping artifact persists even for large samples and dense markers and may cause underreporting of polygenicity from genetic crosses."<a href="https://doi.org/10.1073/pnas.2300959120" rel="nofollow noopener" translate="no" target="_blank">https://doi.org/10.1073/pnas.2300959120</a>

Flávia E. RiusIf you want to learn more about - complex traits; - <a href="https://fosstodon.org/tags/GWAS" class="mention hashtag" rel="tag">#GWAS</a>; - <a href="https://fosstodon.org/tags/polygenic" class="mention hashtag" rel="tag">#polygenic</a> scores,I have created a playlist in youtube with some great lectures and discussions from Broad Institute's Medical Population Genetics department.Check it out: <a href="https://youtube.com/playlist?list=PLSTeUJbSJXfnUjstgtx2cTKWsCBJpnvGy" target="_blank" rel="nofollow noopener" translate="no">https://youtube.com/playlist?list=PLSTeUJbSJXfnUjstgtx2cTKWsCBJpnvGy</a>

American NaturaliﬆCryptic <a href="https://ecoevo.social/tags/sexChromosome" class="mention hashtag" rel="nofollow noopener" target="_blank">#sexChromosome</a> was found after removing a master sex-determining <a href="https://ecoevo.social/tags/chromosome" class="mention hashtag" rel="nofollow noopener" target="_blank">#chromosome</a>. This result suggests that <a href="https://ecoevo.social/tags/polygenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#polygenic</a> <a href="https://ecoevo.social/tags/sexDetermination" class="mention hashtag" rel="nofollow noopener" target="_blank">#sexDetermination</a> system may be more prevalent than previously thought.Open access article by Kitano et al. now available ahead of print! <a href="https://www.journals.uchicago.edu/doi/10.1086/724840" rel="nofollow noopener" target="_blank">https://www.journals.uchicago.edu/doi/10.1086/724840</a>

John Belmont<a href="https://fosstodon.org/tags/genomics" class="mention hashtag" rel="tag">#genomics</a> <a href="https://fosstodon.org/tags/genetics" class="mention hashtag" rel="tag">#genetics</a> <a href="https://fosstodon.org/tags/medicine" class="mention hashtag" rel="tag">#medicine</a> <a href="https://fosstodon.org/tags/pediatrics" class="mention hashtag" rel="tag">#pediatrics</a> <a href="https://fosstodon.org/tags/polygenic" class="mention hashtag" rel="tag">#polygenic</a> <a href="https://fosstodon.org/tags/causalinference" class="mention hashtag" rel="tag">#causalinference</a>

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