DoomsdaysCW<p><a href="https://kolektiva.social/tags/Coinfection" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Coinfection</span></a> of <a href="https://kolektiva.social/tags/dengue" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>dengue</span></a> and <a href="https://kolektiva.social/tags/Zika" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Zika</span></a> viruses mutually enhances viral replication in the <a href="https://kolektiva.social/tags/mosquito" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mosquito</span></a> <a href="https://kolektiva.social/tags/AedesAegypti" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AedesAegypti</span></a></p><p>Daniel Chieh-Ding Lin, Shih-Che Weng , Po-Nien Tsao, Justin Jang Hann Chu, Shin-Hong Shiao </p><p>Full text links<br>full text provider logo<br>Actions<br>Share</p><p>Page navigation</p><p> Title & authors<br> Abstract<br> Conflict of interest statement<br> Figures<br> Similar articles<br> References<br> MeSH terms<br> Related information<br> Grants and funding<br> LinkOut - more resources</p><p>Parasit Vectors, 2023 May 11</p><p>"Abstract</p><p>Background: The mosquito Aedes aegypti transmits two of the most serious mosquito-borne viruses, dengue virus (DENV) and Zika virus (ZIKV), which results in significant human morbidity and mortality worldwide. The quickly shifting landscapes of DENV and ZIKV endemicity worldwide raise concerns that their co-circulation through the Ae. aegypti mosquito vector could greatly exacerbate the disease burden in humans. Recent reports have indicated an increase in the number of co-infection cases in expanding co-endemic regions; however, the impact of co-infection on viral infection and the detailed molecular mechanisms remain to be defined.</p><p>Conclusions: Our results suggest that DENV2 and ZIKV simultaneously establishing infection in the Ae. aegypti mosquito vector may augment one another during replication. The data also implicate the homologous NS5 protein as a key intersection between the flaviviruses in co-infection, highlighting it as a potential target for vector control."</p><p><a href="https://pubmed.ncbi.nlm.nih.gov/37165438/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pubmed.ncbi.nlm.nih.gov/371654</span><span class="invisible">38/</span></a></p>