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Science NewsScientists at @uni_mainz_eng & @imbmainz propose a concept of a <a href="https://idw-online.social/tags/ProteinAggregation" class="mention hashtag" rel="nofollow noopener" target="_blank">#ProteinAggregation</a> clock to measure <a href="https://idw-online.social/tags/ageing" class="mention hashtag" rel="nofollow noopener" target="_blank">#ageing</a> and <a href="https://idw-online.social/tags/health" class="mention hashtag" rel="nofollow noopener" target="_blank">#health</a> / Potential new way for detecting the risk of getting <a href="https://idw-online.social/tags/AgeRelatedDiseases" class="mention hashtag" rel="nofollow noopener" target="_blank">#AgeRelatedDiseases</a> // <a href="https://idw-online.social/tags/neurodegeneration" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurodegeneration</a> <a href="https://idw-online.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloid</a> <a href="https://idw-online.social/tags/AgeingResearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#AgeingResearch</a> <a href="https://idw-online.social/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> <a href="https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock" rel="nofollow noopener" translate="no" target="_blank">https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock</a>

idw_onlineScientists at @uni_mainz_eng & @imbmainz propose a concept of a <a href="https://idw-online.social/tags/ProteinAggregation" class="mention hashtag" rel="nofollow noopener" target="_blank">#ProteinAggregation</a> clock to measure <a href="https://idw-online.social/tags/ageing" class="mention hashtag" rel="nofollow noopener" target="_blank">#ageing</a> and <a href="https://idw-online.social/tags/health" class="mention hashtag" rel="nofollow noopener" target="_blank">#health</a> / Potential new way for detecting the risk of getting <a href="https://idw-online.social/tags/AgeRelatedDiseases" class="mention hashtag" rel="nofollow noopener" target="_blank">#AgeRelatedDiseases</a> // <a href="https://idw-online.social/tags/neurodegeneration" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurodegeneration</a> <a href="https://idw-online.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloid</a> <a href="https://idw-online.social/tags/AgeingResearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#AgeingResearch</a> <a href="https://idw-online.social/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> <a href="https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock" rel="nofollow noopener" translate="no" target="_blank">https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock</a>

CellBioNews<a href="https://scientificnetwork.de/tags/Molecular" class="mention hashtag" rel="nofollow noopener" target="_blank">#Molecular</a> cooperation at the threshold of <a href="https://scientificnetwork.de/tags/life" class="mention hashtag" rel="nofollow noopener" target="_blank">#life</a>.<a href="https://scientificnetwork.de/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> <a href="https://scientificnetwork.de/tags/nucleic_acids" class="mention hashtag" rel="nofollow noopener" target="_blank">#nucleic_acids</a> <a href="https://phys.org/news/2023-11-molecular-cooperation-threshold-life.html" rel="nofollow noopener" translate="no" target="_blank">https://phys.org/news/2023-11-molecular-cooperation-threshold-life.html</a>

Sjors ScheresRead tomorrow's Nature to find out what we think 7 years of solving <a href="https://fosstodon.org/tags/cryoEM" class="mention hashtag" rel="tag">#cryoEM</a> structures of brain-derived <a href="https://fosstodon.org/tags/amyloids" class="mention hashtag" rel="tag">#amyloids</a> has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon; very grateful to present and past group members. <a href="https://rdcu.be/dnaXd" target="_blank" rel="nofollow noopener" translate="no">https://rdcu.be/dnaXd</a>

Sjors ScheresComing Thursday, we have a big review coming out about our work on <a href="https://fosstodon.org/tags/cryoEM" class="mention hashtag" rel="tag">#cryoEM</a> structures of <a href="https://fosstodon.org/tags/amyloids" class="mention hashtag" rel="tag">#amyloids</a> in the past 6-7 years. I will promote on Twitter, Mastodon and BlueSky, and analyse interactions on the different platforms.

PastelBioRT @ProteinSociety: The September newsletter is out, with thoughts about AI/ChatGPT, and choosing the right freezer for your research lab! Check it out here: <a href="https://lnkd.in/gR2xqfEu" rel="nofollow noopener" target="_blank">https://lnkd.in/gR2xqfEu</a> <a href="https://lnkd.in/gmEUGxGQ" rel="nofollow noopener" target="_blank">https://lnkd.in/gmEUGxGQ</a> <a href="https://mstdn.science/tags/proteinscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#proteinscience</a> <a href="https://mstdn.science/tags/ai" class="mention hashtag" rel="nofollow noopener" target="_blank">#ai</a> <a href="https://mstdn.science/tags/chatgpt" class="mention hashtag" rel="nofollow noopener" target="_blank">#chatgpt</a> <a href="https://mstdn.science/tags/proteindynamics" class="mention hashtag" rel="nofollow noopener" target="_blank">#proteindynamics</a> <a href="https://mstdn.science/tags/microscopy" class="mention hashtag" rel="nofollow noopener" target="_blank">#microscopy</a> <a href="https://mstdn.science/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> <a href="https://mstdn.science/tags/scientificwebinar" class="mention hashtag" rel="nofollow noopener" target="_blank">#scientificwebinar</a> <a href="https://lnkd.in/gR2xqfEu" rel="nofollow noopener" target="_blank">https://lnkd.in/gR2xqfEu</a>

Victoria Stuart 🇨🇦 🏳️‍⚧️... cont'd 14/14 [scroll/page up for prev. content]Related hashtags for this Long COVID discussion<a href="https://mastodon.social/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> <a href="https://mastodon.social/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://mastodon.social/tags/SARScov2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARScov2</a> <a href="https://mastodon.social/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#LongCOVID</a> <a href="https://mastodon.social/tags/1918flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#1918flu</a> <a href="https://mastodon.social/tags/PublicHealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#PublicHealth</a> <a href="https://mastodon.social/tags/pandemics" class="mention hashtag" rel="nofollow noopener" target="_blank">#pandemics</a> <a href="https://mastodon.social/tags/LongFlu" class="mention hashtag" rel="nofollow noopener" target="_blank">#LongFlu</a> <a href="https://mastodon.social/tags/SpanishFlu" class="mention hashtag" rel="nofollow noopener" target="_blank">#SpanishFlu</a> <a href="https://mastodon.social/tags/PAIS" class="mention hashtag" rel="nofollow noopener" target="_blank">#PAIS</a> <a href="https://mastodon.social/tags/PostAcuteInfectionSyndrome" class="mention hashtag" rel="nofollow noopener" target="_blank">#PostAcuteInfectionSyndrome</a> <a href="https://mastodon.social/tags/RiskAvoidance" class="mention hashtag" rel="nofollow noopener" target="_blank">#RiskAvoidance</a> <a href="https://mastodon.social/tags/RiskAversion" class="mention hashtag" rel="nofollow noopener" target="_blank">#RiskAversion</a> <a href="https://mastodon.social/tags/EllsbergParadox" class="mention hashtag" rel="nofollow noopener" target="_blank">#EllsbergParadox</a> <a href="https://mastodon.social/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> <a href="https://mastodon.social/tags/neurobiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurobiology</a> <a href="https://mastodon.social/tags/LewyBody" class="mention hashtag" rel="nofollow noopener" target="_blank">#LewyBody</a> <a href="https://mastodon.social/tags/LewyBodies" class="mention hashtag" rel="nofollow noopener" target="_blank">#LewyBodies</a> <a href="https://mastodon.social/tags/neurodegradation" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurodegradation</a> <a href="https://mastodon.social/tags/CellBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CellBiology</a> <a href="https://mastodon.social/tags/ParkinsonsDisease" class="mention hashtag" rel="nofollow noopener" target="_blank">#ParkinsonsDisease</a> <a href="https://mastodon.social/tags/parkinsonism" class="mention hashtag" rel="nofollow noopener" target="_blank">#parkinsonism</a> <a href="https://mastodon.social/tags/ProteinMisfolding" class="mention hashtag" rel="nofollow noopener" target="_blank">#ProteinMisfolding</a> <a href="https://mastodon.social/tags/alphaSynuclein" class="mention hashtag" rel="nofollow noopener" target="_blank">#alphaSynuclein</a> <a href="https://mastodon.social/tags/synucleinopathy" class="mention hashtag" rel="nofollow noopener" target="_blank">#synucleinopathy</a> <a href="https://mastodon.social/tags/synucleinopathies" class="mention hashtag" rel="nofollow noopener" target="_blank">#synucleinopathies</a> <a href="https://mastodon.social/tags/DreamEnactmentSleepDisorder" class="mention hashtag" rel="nofollow noopener" target="_blank">#DreamEnactmentSleepDisorder</a> <a href="https://mastodon.social/tags/SleepDisorders" class="mention hashtag" rel="nofollow noopener" target="_blank">#SleepDisorders</a>

ISOGG“Investigating this further, the researchers found antibodies in the three patients that bound specifically to ATTR amyloid deposits in mouse and human tissue and to synthetic ATTR amyloid. No such antibodies were present in 350 other patients in the cohort with a typical clinical course.” <a href="https://genealysis.social/tags/dna" class="mention hashtag" rel="nofollow noopener" target="_blank">#dna</a> <a href="https://genealysis.social/tags/Amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#Amyloids</a> <a href="https://genealysis.social/tags/isogg" class="mention hashtag" rel="nofollow noopener" target="_blank">#isogg</a> <a href="https://genealysis.social/tags/geneadons" class="mention hashtag" rel="nofollow noopener" target="_blank">#geneadons</a> <a href="https://genealysis.social/tags/ucl" class="mention hashtag" rel="nofollow noopener" target="_blank">#ucl</a> <a href="https://medicalxpress.com/news/2023-06-devastating-heart-condition-reversed.html" rel="nofollow noopener" target="_blank">https://medicalxpress.com/news/2023-06-devastating-heart-condition-reversed.html</a>

Sjors ScheresI can highly recommend @WenjuanZhang11: she is a fantastic scientist and a wonderful person. Work with her on <a href="https://fosstodon.org/tags/cryoEM" class="mention hashtag" rel="tag">#cryoEM</a> of yeast <a href="https://fosstodon.org/tags/amyloids" class="mention hashtag" rel="tag">#amyloids</a>! --- RT @WenjuanZhang11 We are recruiting a <a href="https://fosstodon.org/tags/postdoc" class="mention hashtag" rel="tag">#postdoc</a> to join our team @MRC_Prion at @ucl for studying <a href="https://fosstodon.org/tags/CryoEM" class="mention hashtag" rel="tag">#CryoEM</a> structures of prion-like protein assemblies in neurodegenerative diseases and yeast model. More information and apply link are here: <a href="http://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details…" target="_blank" rel="nofollow noopener" translate="no">http://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details…</a> <a href="https://twitter.com/WenjuanZhang11/status/1630577935831662593" target="_blank" rel="nofollow noopener" translate="no">https://twitter.com/WenjuanZhang11/status/1630577935831662593</a>

Sjors ScheresThe identity of extra densities in <a href="https://fosstodon.org/tags/cryoEM" class="mention hashtag" rel="tag">#cryoEM</a> maps of <a href="https://fosstodon.org/tags/amyloids" class="mention hashtag" rel="tag">#amyloids</a> from brains remains unknown, and a major focus of research. Just because a model fits in these fuzzy densities does not mean much, and writing speculative papers is going to be of little help. <a href="https://www.biorxiv.org/content/10.1101/2023.02.01.526613v1" target="_blank" rel="nofollow noopener" translate="no">https://www.biorxiv.org/content/10.1101/2023.02.01.526613v1</a>

Borja RodríguezNew approved anti-amyloid Ab, super good news! But, why is it approved when there are still long term adversities? <a href="https://www.nejm.org/doi/full/10.1056/NEJMc2215907?query=recirc_curatedRelated_article" rel="nofollow noopener" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMc2215907?query=recirc_curatedRelated_article</a><a href="https://mstdn.social/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> <a href="https://mstdn.social/tags/alzheimersdisease" class="mention hashtag" rel="nofollow noopener" target="_blank">#alzheimersdisease</a>

Patrick van der Wel(It is in part a follow-up on our earlier collaborative paper, more focused on the <a href="https://mastodon.social/tags/DNP" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNP</a> <a href="https://mastodon.social/tags/SSNMR" class="mention hashtag" rel="nofollow noopener" target="_blank">#SSNMR</a> analysis of unlabeled <a href="https://mastodon.social/tags/polyQ" class="mention hashtag" rel="nofollow noopener" target="_blank">#polyQ</a> <a href="https://mastodon.social/tags/protein" class="mention hashtag" rel="nofollow noopener" target="_blank">#protein</a> <a href="https://mastodon.social/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a> - <a href="https://pubs.acs.org/doi/10.1021/jacs.8b09002" rel="nofollow noopener" target="_blank">https://pubs.acs.org/doi/10.1021/jacs.8b09002</a> )

Morten Kam Dahl DueholmMost <a href="https://mstdn.science/tags/Pseudomonas" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pseudomonas</a> <a href="https://mstdn.science/tags/aeruginosa" class="mention hashtag" rel="nofollow noopener" target="_blank">#aeruginosa</a> strains encode functional <a href="https://mstdn.science/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a>. However, the biological role of these <a href="https://mstdn.science/tags/biofilm" class="mention hashtag" rel="nofollow noopener" target="_blank">#biofilm</a> components have so far remained unknown. Here, we use a rat 🐀 model to show that they can br implicated in lung 🫁 infections. <a href="https://journals.asm.org/doi/10.1128/spectrum.03071-22" rel="nofollow noopener" target="_blank">https://journals.asm.org/doi/10.1128/spectrum.03071-22</a>

Sjors ScheresJust in case this leads to the suspension of my account, 👋<a href="https://fosstodon.org/tags/goodbye" class="mention hashtag" rel="tag">#goodbye</a>! I get most of my science (<a href="https://fosstodon.org/tags/cryoEM" class="mention hashtag" rel="tag">#cryoEM</a>, <a href="https://fosstodon.org/tags/amyloids" class="mention hashtag" rel="tag">#amyloids</a>, <a href="https://fosstodon.org/tags/Alzheimers" class="mention hashtag" rel="tag">#Alzheimers</a>) and other news here; and am 🥰 grateful to my 12.5k followers for their interest. I would miss this all dearly, but there are limits...

Patrick van der Wel“How important is the N-terminal acetylation of alpha-synuclein for its function and aggregation into <a href="https://mastodon.social/tags/amyloids" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloids</a>?” by <a href="https://mastodon.social/@vinsub" class="u-url mention" rel="nofollow noopener" target="_blank">@vinsub</a> <a href="https://www.frontiersin.org/articles/10.3389/fnins.2022.1003997/full" rel="nofollow noopener" target="_blank">https://www.frontiersin.org/articles/10.3389/fnins.2022.1003997/full</a> <a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener" target="_blank">#amyloid</a> <a href="https://mastodon.social/tags/parkinsons" class="mention hashtag" rel="nofollow noopener" target="_blank">#parkinsons</a>

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