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#hidradenitis

1 post1 participant0 posts today
Continued thread
Maikel 🇪🇺 🇪🇸

I'm a bit concern the cyst on the armpit isn't getting any smaller but bigger.

Is not a spot, is not an "attempt" to cyst, it is a fully-fledged cyst. And the worst thing that could happen if it doesn't get any smaller soon is tunneling.

THIS is my biggest fear.

Once it gets into tunnelling (that is conencting different areas under the skin) the only way out is surgery.

I can't run either while this goes on, and I have to drastically avoid sweating (gym is fine, air con to the max) because it also makes it worse.

Diet wise I should be heading to an AIP temporary diet while this is ongoing.

#hidradenitis
Maikel

The symmetry of it all is what screams autoimmune.

Clindamicine should clear it quickly and the metformin should prevent it from appearing while I keep losing fat.

We'll see. I hope so.

#hidradenitis

Eli Roberson (he/him)

After a long, long incubation, Dr. Dave Morales-Heil's paper is out in HGGA.

cell.com/hgg-advances/fulltext

The long and short of it is he found what we think is the first new gene associated with risk for hidradenitis suppurativa since the familial association with gamma-secretase genes was found > 10 years ago. And perhaps the first association with any form of HS, not just familial HS.

Human Genetics and Genomics AdvancesRare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativaHidradenitis suppurativa (HS) is a chronic inflammatory skin disease with an appreciable genetic risk component. We confirmed additional high penetrance loss of function variants in NCSTN. Additionally, we found a significantly increased burden of rare missense variants in the SH3 domain of PSTPIP1in patients with HS.
#Genetics#Genomics#Bioinformatics
Gabriele Pollara

Secukinumab blocks IL-17 and some evidence of efficacy in hidradenitis suppurativa in 2x RCT.

Interesting in so much this is clearly an inflammatory disease in which there is also undoubtedly an infective component.

These studies, along with efficacy of TNF blockade indicates hyperinflammation the main issue.

#immunology #inflammation #hidradenitis #IL17 #secukinumab #RCT #trial #hyperinflammation

thelancet.com/journals/lancet/

The LancetSecukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised, placebo-controlled, double-blind phase 3 trialsWhen given every 2 weeks, secukinumab was clinically effective at rapidly improving signs and symptoms of hidradenitis suppurativa with a favourable safety profile and with sustained response up to 52 weeks of treatment.
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