Learning about hormones is always bittersweet: on the one hand, it brings the sweet vindication of "I knew it wasn't all in my head", on the other hand - the bitterness that certain professionals *should* know better. Today about progesterone:
#endocrinology
0 posts0 participants0 posts today
There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis.
'Cocaine Self-Administration Differentially Modulates the Content of Cholesterol, Progesterone, and Testosterone in the Brain and Plasma of Male Rats' - a Karger #Endocrinology article on #ScienceOpen:
https://www.scienceopen.com/document?vid=55335351-e7f3-4e1b-9bc9-a4ebcddaa150
ScienceOpenCocaine Self-Administration Differentially Modulates the Content of Cholesterol, Progesterone, and Testosterone in the Brain and Plasma of Male Rats<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d2623134e140">
<b>
<i>Introduction:</i>
</b> Chronic cocaine exposure results in changes in circulating steroid hormones, which
is known to be associated with cocaine-seeking and cocaine-taking behavior. However,
whether cocaine also alters the brain content of these steroid hormones and cholesterol,
a precursor to all steroid hormones, has yet to be extensively investigated. Thus,
the goal of this study was to determine whether cocaine self-administration (SA) altered
the content of cholesterol and steroid hormones (progesterone and testosterone) in
both the plasma and the brain of animals.
<b>
<i>Methods:</i>
</b> Male Sprague-Dawley rats were allowed to self-administer cocaine (1.5 mg/kg/infusion)
for a maximum of 40 injections within 6 h per day for 5 consecutive days followed
by cue reactivity test and cocaine SA under the progressive ratio schedule as a measure
of motivation to acquire cocaine. Eighteen hours after the last behavior test, the
blood and brain tissue, including the prefrontal cortex (PFC) and dorsal striatum
(CPu), were collected for biochemical assays.
<b>
<i>Results:</i>
</b> While cocaine SA did not alter the content of cholesterol and progesterone in the
plasma, it reduced cholesterol content and almost completely abolished progesterone
content in both the PFC and CPu. Further, testosterone levels were reduced in the
CPu and plasma. Notably, plasma testosterone was positively correlated with its content
in the PFC and CPu.
<b>
<i>Conclusions:</i>
</b> Cholesterol and progesterone in the brain are more sensitive to changes induced by
cocaine SA than those in the plasma. Future studies should focus on understanding
the functional consequence of altered brain steroids on neurotransmission and cocaine-seeking
and cocaine-taking behavior.
</p>
https://www.europesays.com/us/47795/ New gene editing approach targets mutation behind common genetic heart disease #bioengineering #Blood #cardiomyopathy #diabetes #dna #endocrinology #Gene #GeneEditing #genetic #Genetics #Heart #HeartDisease #HypertrophicCardiomyopathy #medicine #Molecule #Mutation #protein #Science #UnitedStates #UnitedStates #US
https://www.europesays.com/us/7430/ Marquis Who’s Who Honors Mahyar Heydarpour, PhD, for Expertise in Medicine and Higher Education #endocrinology #Genetics #genomics #HarvardMedicalSchool #MahyarHeydarpour #PerioperativeGenomicsCenter #professor #Science #UnitedStates #UnitedStates #UniversityOfGuelph #US
Despite what you learned at school, insulin isn’t just made in the pancreas
#Health #BrainInsulin #Endocrinology #Type1Diabetes #Type2Diabetes #Neuroscience #InsulinProduction #BrainHealth #Alzheimers #InsulinResistance #Neurology #Endocrinology #Hormones
https://the-14.com/despite-what-you-learned-at-school-insulin-isnt-just-made-in-the-pancreas/
'Alterations of #Brain white matter network topological properties in overt #Hypothyroidism' - a Society for #Endocrinology #Research article by Bioscientifica on #ScienceOpen: https://www.scienceopen.com/document?vid=37f91fe6-0788-4b07-86a5-4dbe442070a4
ScienceOpenAlterations of brain white matter network topological properties in overt hypothyroidism<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d873502e282">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d873502e283">Purpose</h5>
<p dir="auto" id="d873502e285">This study examined the topological properties of brain white matter networks in overt
hypothyroidism (OH) patients and their links to cognitive and emotional dysfunction.
</p>
</div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d873502e287">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d873502e288">Materials and methods</h5>
<p dir="auto" id="d873502e290">Fifty OH patients and 92 healthy controls underwent brain magnetic resonance imaging,
clinical assessments and neuropsychological evaluations. Graph-theoretical network
analysis based on diffusion tensor imaging was used to calculate global and local
topological properties. Between-group differences were analyzed, and partial correlation
and mediation analyses were conducted to explore relationships among topological metrics,
clinical variables and neuropsychological scores.
</p>
</div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d873502e292">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d873502e293">Results</h5>
<p dir="auto" id="d873502e295">The OH group showed significantly higher depressive and anxious scores, and lower
cognitive scores. In the global topological analysis, the OH group showed decreased
global efficiency, which was negatively correlated with the Hamilton Rating Scale
for Depression-24 scores. Local topological abnormalities were predominantly observed
in the nodal efficiency (NE), degree centrality and nodal local efficiency of several
regions within the limbic system and default mode networks. Notably, NE in the left
amygdala and left paracentral lobule was negatively correlated with the Hamilton Rating
Scale for Depression-24 scores, and decreased NE in the right median cingulate and
paracingulate gyri was positively correlated with executive function/visuospatial
ability scores and the clock drawing test score.
</p>
</div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d873502e297">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d873502e298">Conclusion</h5>
<p dir="auto" id="d873502e300">OH patients show depression, anxiety and cognitive impairments linked to global efficiency
and regional abnormalities in the limbic system and default mode network. These findings
provide insights into the neuropathophysiological mechanisms underlying emotional
and cognitive impairments.
</p>
</div>
Prevalence and underdiagnosis of diabetes mellitus in a food insecure population https://www.diningandcooking.com/2008559/prevalence-and-underdiagnosis-of-diabetes-mellitus-in-a-food-insecure-population/ #Diabetes #diseases #Endocrinology #food #FoodInsecurity #HealthCare #HumanitiesAndSocialSciences #multidisciplinary #PreDiabetes #prevention #RiskFactors #science
Eating distractions as predictors of ultra-processed food consumption and Mediterranean diet adherence in adolescents https://www.diningandcooking.com/1962965/eating-distractions-as-predictors-of-ultra-processed-food-consumption-and-mediterranean-diet-adherence-in-adolescents/ #DistractedEating #EatingHealthy #Endocrinology #HumanitiesAndSocialSciences #Mediterranean #MediterraneanFood #MindfulEating #multidisciplinary #nova #RiskFactors #science #Youths
High cortisol isn’t a health concern for most people, despite claims you may have seen online. Wellness influencers blame cortisol for a host of ailments, including bloating, fatigue, irritability and overly “puffy” faces and waists.
#healthcare #biology #wellness #endocrinology #hormones #stress #health
https://www.washingtonpost.com/wellness/2025/02/17/cortisol-levels-high/
The Washington Post · Column | What people get wrong about cortisol, the ‘stress hormone’Despite claims popularized on social media, high cortisol isn’t a health concern for most of us.
Any #science #endocrinology #doctor types or knowledgeable patients out there?
Have some questions before I spend money I don’t have re #DHEA & #pregnenolone.:
I’m trying to find a good compounding chemist in #Melbourne #Ausralia to compound DHEA (it’s illegal in Aus to buy off the shelf, need compounding prescription & permit- got both).
BUT! I’m getting confused by the chemists. Some say I must get a DHEA troche or a capsule will convert straight to #estrogen or #testosterone, no chance to tap DHEA receptors (unsure if they exist). I’ve also read it modulated other receptors before being metabolised.Wouldn’t I be better off w a cream in that case? Other compounders say there’s no difference. BS?
I thought #pregnenolone
might help more. It’s the ‘mother hormone’, right?
Since I caught #COVID19 I’m mostly producing low hormones but it varies. Cortisol normalised, still on thyroid meds, oestrogen shot up, no DHEA or testosterone…plus much more going on.
Any #science #endocrinology #doctor types out there?
Have some questions before I spent money I don’t have:
#DHEA: Can anyone w science background/knowledgeable patient help with this?
I’m trying to find a good compounding chemist (DHEA illegal in Aus without compounding prescription & permit- got both)
BUT! I’m getting confused by the chemists. Some say I must get a DHEA troche or will convert straight to #estrogen or #testosterone as capsule, no chance to tap DHEA receptors. Ive also read it taps & modulates other receptors beforehand. Wouldn’t I be better off w a cream in that case? Other compounders say there’s no difference. BS? Halp.
I thought #pregnenolone might help more. It’s the ‘mother hormone’, right?
Since I caught #COVID19 I’m mostly producing low #hormones but it can varies (some up, others down, some normalise after a time. Cortisol normalised, still on thyroid meds, oestrogen shot up, no DHEA or testosterone… much more.
Can anyone help? I’ve been through multiple doctors, asked pharmacist and they all contradict themselves and each other or don’t know what either home does.
Don’t ever get #ChronicIllness
You’ll up relying on people who don’t know how medicine works. Very few knowledgeable people.
#stem #science #health #endocrinology #spiffy
Scientician wants to better understand the molecular basis of circadian timekeeping and HOLY COW DAYLIGHT SAVINGS STARTS THIS WEEKEND
Medical Xpress · Explaining how our biological clocks work and how to better regulate our circadian rhythms
Has anyone taken raloxifene (as non-binary feminising HRT), and not subsequently switched to oestradiol (E2)?
The poll's really just in case someone says "yes" but doesn't want to comment. I'm happy to receive answers in the far future. (I'm trying to study endocrinology through the medium of anecdote.)
New #French #Guidelines #Recommend #Trans #Youth receive #GenderAffirmingCare, Denounce "#WaitAndSee" #Approach.
The new #guidelines, published by the #French #Society of #Pediatric #Endocrinology and #Diabetology, create a #national #medical #consensus on #genderaffirmingcare in #France.
#Women #Transgender #LGBTQ #LGBTQIA #EuropeanUnion #France #TransKids #GenderAffirmingCare #Science #Progress
https://www.erininthemorning.com/p/new-french-guidelines-recommend-trans
Erin In The Morning · New French Guidelines Recommend Trans Youth Care, Denounce "Wait-And-See" Approach
The study in mice concluded that eating fewer calories—caloric restriction (CR)—had a greater impact on lifespan than intermittent fasting (IF), revealing that very low calorie diets generally extended an animal’s lifespan regardless of their body fat or glucose levels—both typically seen as markers of metabolic health and aging.
#health #aging #physiology #pathology #nutrition #diet #endocrinology #biology
https://www.genengnews.com/topics/translational-medicine/caloric-restriction-vs-intermittent-fasting-large-mouse-study-offers-insights-and-raises-questions
GEN - Genetic Engineering and Biotechnology News · Caloric Restriction vs. Intermittent Fasting: Large Mouse Study Offers Insights and Raises Questions
Funny thing about thyroid problems and dyscalculia: the way TSH is calculated is super confusing to my brain, so I read it as my TSH being high. Turns out it's low, but it has been for long enough, (and far enough out of healthy range) for my endocrinologist to be concerned.
So I have Subclinical Hypothyroidism.
Any #pwME have Thyroid issues?
I may have Hyperthyroidism which is so interesting to me, since Hypothyroidism was ruled out before I was diagnosed with ME/CFS almost 2 decades ago and my thyroid panel was always a little low until very recently.
Assessing diagnostic tools in #endocrinology with computer simulations https://link.medium.com/qDCugbiYZMb
The new research, published Friday in the journal JAMA Network Open, found that intermittent fasting had striking metabolic benefits that surpassed even the effects of prescription medications for people with newly diagnosed diabetes.
#PublicHealth #nutrition #healthcare #diet #wellbeing #fasting #pathology #diseases #endocrinology
https://www.washingtonpost.com/wellness/2024/06/21/intermittent-fasting-type-2-diabetes/
Washington Post · Intermittent fasting over two days can help people with Type 2 diabetesA study found that intermittent fasting had striking metabolic benefits that surpassed the effects of prescription drugs for people with newly diagnosed diabetes.