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#COVID_19

9 posts4 participants2 posts today
Continued thread
Public
Tom Kindlon

3/
Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with #longCOVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial

Image is from latest Science for ME weekly update

thelancet.com/journals/laninf/

@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19

The Lancet Infectious Diseases Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial — Mitsuaki Sawano et al. "Nirmatrelvir–ritonavir administered for 15 days did not significantly improve health outcomes in participants with long COVID compared with placebo–ritonavir at day 28."
Public
Tom Kindlon

"Does Paxlovid reduce #longCOVID symptoms? Yale-led trial finds out"
eurekalert.org/news-releases/1

"PAX LC team pioneered a novel, decentralized design that brought the trial into 100 participants’ homes...first fully decentralized phase 2 trial of its scale"

Method could be useful in #MEcfs

@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @mecfs

News Release 7-Apr-2025 Does Paxlovid reduce long COVID symptoms? Yale-led trial finds out Peer-Reviewed Publication Yale University Antiviral medications nirmatrelvir/ritonavir (Paxlovid) were not effective in relieving long COVID symptoms, according to a new study published in The Lancet Infectious Diseases on April 3. The findings came from the Yale Paxlovid for Long COVID (PAX LC) Trial, led by principal investigator Dr. Harlan Krumholz, Harold H. Hines, Jr. Professor of Medicine (Cardiology), and Akiko Iwasaki, Sterling Professor of Immunobiology. The phase 2 investigational new drug clinical trial tested whether a 15-day course of Paxlovid, an FDA-approved antiviral for acute COVID-19, could also help long COVID patients. The PAX LC team pioneered a novel, decentralized design that brought the trial into 100 participants’ homes around the nation. It’s the first fully decentralized phase 2 trial of its scale, the researchers say.
Public
Tom Kindlon

US research

Dysautonomia in long COVID is prevalent and could explain the frequency of symptoms

medrxiv.org/content/10.1101/20

#dysautonomia @dysautonomia #pots @pots @longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2

medRxiv · Dysautonomia in long COVID is prevalent and could explain the frequency of symptomsBackground Long COVID presents with a variety of symptoms. Some of those symptoms could be related to autonomic dysfunction. Our aim is to evaluate the prevalence of autonomic dysfunction in long COVID patients. Methods We conducted a cross-sectional study and included all consecutive patients enrolled in several clinical research studies. We performed the following autonomic dysfunction markers: heart rate variability, heart rate, systolic and diastolic blood pressure changes during NASA lean test, cardiopulmonary exercise testing and a COMPASS-31 scale. We used linear regression to calculate the contribution of each dysautonomia measure on symptom burden as measured by the modified COVID-19 Yorkshire scale. Results We included 100 patients for this study. Our sample had a mean age of 56+/-11 years, included 53% minorities and 32% were women. Dysautonomia as defined by an abnormal COMPASS-31 was seen in 82%; 95% 72-89 while cardiovascular resting dysautonomia as represented by an abnormal heart rate variability was seen in 60%; 95% 48-70 of the population, orthostatic hypotension in 12% and POTS in 10%. In our adjusted analysis, we found that the beta coefficient for the COMPASS-31 score (0.37) was significant on changes in a self-reported long COVID symptom burden. The orthostatic intolerance and gastrointestinal domains of the COMPASS-31 was associated the highest long COVID symptom burden. Conclusion Dysautonomia is common in long COVID patients and contributes to the overall symptoms seen in long COVID. Identifying dysautonomia has important diagnostic and therapeutic implications. ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial NA ### Funding Statement Yes ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: All studies were approved by the research ethics committees at the Miami VAHS and NOVA Southeastern University and all participants signed informed consent prior to participation. Miami VA is the IRB of record I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data cannot be shared publicly because it is owned but the Veterans Affairs.
Public
Tom Kindlon

New UK research:

Long-term effects of #SARSCoV2 infection on blood vessels and blood pressure

journals.lww.com/jhypertension

"Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension & cardiovascular disease”

@longcovid
#LongCovid #PwLC #LC #PASC #postcovid
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver

Graphical abstract
Public
Tom Kindlon

From India:
Early biomarkers in hospitalized patients as predictors of post-acute sequelae of SARS-CoV-2 infection: a one-year cohort study

bmcinfectdis.biomedcentral.com

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

BMC Infectious Diseases Early biomarkers in hospitalized patients as predictors of post-acute sequelae of SARS-CoV-2 infection: a one-year cohort study — Nair et al. "A cohort of 120 adult patients, including 50 intensive care and 70 non-intensive care patients, was followed up at two weeks, six weeks, and one-year post-discharge using structured questionnaires. The study integrated comorbidities and laboratory biomarkers to forecast the risk for PASC."
Public
Tom Kindlon

Press release:
"Pregnancy may reduce long COVID risk"
eurekalert.org/news-releases/1

Long COVID after SARS-CoV-2 During Pregnancy in the United States
nature.com/articles/s41467-025

I personally would find this more interesting if this related to the ME-CFS/similar subgroup rather than a mixed LC group

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

News Release 1-Apr-2025 Pregnancy may reduce long COVID risk Peer-Reviewed Publication Weill Cornell Medicine Pregnancy may offer some protection from developing Long COVID, found a new study led by Weill Cornell Medicine, University of Rochester Medical Center, University of Utah Health and Louisiana Public Health Institute. Previous research has mostly focused on non-pregnant adults affected by Long COVID— a condition lasting for months after a person recovers from SARS-CoV-2 infection. The study, published April 1 in Nature Communications, helps fill a critical gap about Long COVID in women infected with SARS-CoV-2 during pregnancy. “This population is so important and vulnerable, but we had no evidence about their Long COVID risk to guide their care,” said Dr. Chengxi Zang, an instructor in population health sciences at Weill Cornell Medicine, who co-led the research. “We hope this new data will help clinicians develop better Long COVID prevention and treatment strategies for pregnant women and help those most at risk.”
Public
Tom Kindlon

Brain Structural Abnormalities in Patients with #PostCOVID -19 Headache

mdpi.com/2035-8377/17/4/50

Retrospective 30 vs 30 MRI case/control study. "One of our most noteworthy findings is that white matter lesions were identified in 50% of the post- #COVID-19 group, compared to 20% in the control group”

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #CovidBrain @covid19 #COVID19 #COVID #COVID_19 #SARSCoV2 #CovidIsNotOver #auscovid19 @auscovid19

Public
Tom Kindlon

The US administration has proposed many cuts that may affect ME/CFS or #LongCovid research

Image is from latest Science for ME weekly update

Links:

science.org/content/article/sa

scientificamerican.com/article

thesicktimes.org/2025/03/28/up

fiercebiotech.com/research/stu

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#PASC #postcovid #postcovid19 #PostCovidSyndrome #COVIDBrain
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19

USA - The current administration has proposed many cuts to the NIH and other departments. Cuts or closures may affect ME/CFS or Long Covid research. The final decision on some cuts is still pending. Science "Saying ‘pandemic is over,’ NIH starts cutting COVID-19 research" Article | Thread Scientific American "HHS’s Long COVID Office Is Closing. What Will This Mean for Future Research and Treatments?" Article | Thread The Sick Times "UPDATE: RECOVER Long COVID pathobiology grants restored" Article | Thread Fierce Healthcare 'It's just ugly': Federal funding cuts to Columbia University leave chronic fatigue research in limbo Article | Thread
Public
Tom Kindlon

"Research finds potential “molecular mimics” behind #COVID -induced #autoimmune disease"

eurekalert.org/news-releases/1

“some of the human proteins the researchers identified as likely targets of COVID-induced #autoimmunity are only found in people with specific genetics”

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome @covid19 #Coronavirus
#COVID19 #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

News Release 26-Mar-2025 Research finds potential “molecular mimics” behind COVID-induced autoimmune disease Peer-Reviewed Publication University of Utah Health COVID infection has been linked to higher risk of autoimmune disorders, including rheumatoid arthritis and type 1 diabetes. But why the virus might cause the body’s immune system to go haywire remains unknown, making it difficult to develop therapies to avoid autoimmunity. One hypothesis is that viral “molecular mimics” that resemble the body’s own proteins trigger an immune response against the virus—and healthy tissues get caught in the crossfire.
Public
Tom Kindlon

From the Netherlands:

Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints

jns-journal.com/article/S0022-

From the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Journal of the Neurological Sciences Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints — Noa van der Knaap et al. "Our results provide additional evidence for microvascular damage in the [Normal Appearing White Matter], which may indicate subtle damage preceding [White Matter Hyperintensities] formation."
Public
Tom Kindlon

From Sweden:
Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19

biorxiv.org/content/10.1101/20

From the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2
@auscovid19 #auscovid19

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 — Ronaldo Lira-Junior et al. "Persistent ISG expression and metabolic perturbations may contribute to long-term immune dysfunction, suggesting that mechanisms observed in COVID-19 could have broader implications for understanding chronic immune activation and post-viral syndromes." "Among the significantly dysregulated metabolites, lipid metabolism exhibited the most profound changes, followed by disruptions in amino acid metabolism."
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