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#cbn

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JADe (he, him)

youtube.com/shorts/mi7cS5z2cJY

ENG: Observational study on medical #cannabis use for 300 people over 50 proves medical #weed effectiveness. Patients favor high CBD low THC oral dosing ( balanced 1:1), to reduce arthritic/chronic pain and help sleep without having to chain smoke/vape. If CBD dominantes there is almost no psychotropic effect.

ESP: Ciencia moderna confirma que #marijuana medicinal alivia dolor crónico, artrítis y sueño. Estudio con 300 personas de más de 50 años revela que pacientes prefieren gotas o comestibles altos en CBD y bajos en THC. Extracto 1:1 de flor resulta aún más efectivo y evita tener que fumar/vapear para sostener efectos analgésicos/ansiolíticos. De dominar el CBD el efecto psicotropico es nulo o mínimo.

#memercredi #viernesdememes #humour #funny #humor #salud #regenerativemedicine #humornegro
#HumourNoir #science #health
#chronicillness #ChronicPainMemes
#chronicpain #thc #cbd #cbn #thca
#sleep #arthritis #cannabinoids
#cannabismedicinal #cannabismedical

ALT-TXT: Monochrome photo of old indigenous woman holding a huge joint between her swollen fingers. Text: SIGNS OF AGING: Swollen Joints

Replied in thread
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JADe (he, him)

@Likewise Great advice ! I am down that road too: low carb chocoholic (now moving on to cocoa nibs) with 6 hours of feed window 5 days a week.

I am 58 years old and insulin resistant. The above nutritional changes plus 40 min of strenght/cardio training every other day, have given me a new lease on life.

My own two bits: walnuts, pecanas, macadamias and avocado provide a lot of healty fats and Omega3/6 balance. When taken at the end of the feeding window, they make the 18 hr fast a piece of... err meatpie 🙄 !

I also make my own cannabinoid extracts. Non psychotropic ones such as cannabinol CBN (main CB2 receptor agonist) and CBD from flower (no hemp) help regulate blood sugar, stabilize mood and protect my liver, spleen colon and pancreas.

Gladly surprised to find your testimony as health does not seem to be a priority for mastodon people...

#health #healthcare #fasting
#ketogenic #ketosis #keto #intermittentfasting #nutrition #endocannabinoidsysten #cbd #cbn #thc #thca #adaptogen
#cbdmedicinal #insulinsensitivity
#insulin #insulina #cannabis #weed #growyourown #herbalist

Diagram depicting which human organs relate to which endocannabinoid receptors. Lungs, brain, vascular system, reproductive organs and muscle behaviour are regulated by CB1 receptors ( anandamide and THC). Colon, spleen and immune system are regulated by CB2 receptors (2-AG and CBN). Bones, pancreas and liver are regulated by both type of receptors.
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Diletta Fileni

La Banca centrale della Nigeria (#CBN) ha venduto valuta estera per un valore di quasi 200 milioni di dollari sul mercato ufficiale, intervenendo per rafforzare la liquidità dopo che la #Naira è scesa del 2,3 percento in tre giorni a seguito dei nuovi dazi statunitensi che hanno scosso i mercati globali e pesato sui prezzi del petrolio.
Mio articolo
#dazi #Nigeria #petrolio #valuta #liquidità #Usa #Trump
corrierepl.it/2025/04/08/niger

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Creebhills

CBN slammed with N4.1bn lawsuit over alleged negligence: Zumax Nigeria Limited, an oil services company, has filed a lawsuit against the Central Bank of Nigeria (CBN) for N4.1 billion, citing gross negligence in a disputed receivership case. In a case presented to Justice Akintoye Aluko of the Federal High Court in Lagos, Zumax accused CBN of failing to oversee banks and safeguard customers. […] creebhills.com/2025/03/cbn-sla #News #CBN

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daltux
:boost: :ciladaBino: Acabo de ouvir pelo #AntennaPod o #podcast que compartilho abaixo como exemplo de cilada causada pela combinação de software privativo de liberdade, gestão de restrições digitais (DRM) e obsolescência programada. Esse tipo de situação esdrúxula ainda é demais normalizado pela mídia dita especializada em tecnologia da informação.

Confira os tipos de manobras que as pessoas se obrigam a realizar para dar alguma mínima função a tornozeleiras eletrônicas de bolso em perfeitas condições físicas, porém inviabilizadas, na prática, pelo software privativo. Possibilidade notável é o último resquício de tecnologia civilizada que os serviços de transmissão de música baseados em DRM ainda permitem — algo que as novas gerações de consumidores vorazes de TRApps estranham e já acham démodé: a Web.

Por fim, ainda me espanto com tamanho fetiche por tal marca específica. Será que um dos fatores seja justamente pela Síndrome de Estocolmo ainda mais exacerbada que na concorrência direta?

💭 Qual é a sua opinião sobre tudo isso? Comente.
#CBN Tecnologia - #Techtudo: Celular velho, música nova: a volta de iPhones antigos como #iPod

Ana Letícia Loubak fala sobre a nova tendência de transformar iPhones antigos em reprodutores de música, substituindo os iPods. A moda tem crescido por motivos de segurança, detox digital e #nostalgia, impulsionando as vendas de celulares usados e iPods na OLX.
⏯️ Arquivo de áudio: https://cbn.mc.tritondigital.com/CBN_TECNOLOGIA_DA_INFORMACAO_P/media/audios/encodeds/3/2025/03/21/458462_20250321.mp3

#celular #música #iphone #apple #streaming #segurança #violência #proprietarySoftware #nonFree #drm #cilada #armadilha #tecnologia #softwarePrivativo #softwareProprietário #SoftwareLivre #FreeSoftware #DefectiveByDesign #Brasil #mobile #celulares #vintage #obsolescência #jornalismo
gnu.orgProprietary Software - GNU Project - Free Software Foundation
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Anna

Also: Does anyone know where to get #CBN gummies an oils (not CBN in small quantities, isolate not great need small quantities of other #cannabinoids & #terpenes for entourage effect). Compounding only used isolates and even more expensive than real #cannabis.

Also plain #THC #gummies or oil.

I need to mix & match depending on day and needs.

In #Australia & have permit. Can no long get it from overseas. All the suppliers I used were threatened by Australian government but meds I need are super expensive or unavailable in Australia. I’m stuck.

I tried vaping. It burned my lungs and throat and aches for a week. Also took me on extremely bad trip.I didn’t get much sleep so vaping isn’t for me. Non-smoker too. I’m trying not to wreck organs still working.

Help appreciated. Let me know if should post this elsewhere for better input. Very energy limited.

@chronicpain @chronicillness

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JADe (he, him)

"The #cannabis plant contains hundreds of chemical compounds. Among them #Cannabinoids , #flavonoids and #terpenes are the most relevant. Delta-nine #THC and #CBD are the most abundant cannabinoids and therefore the most studied.

However there are other minor cannabinoids such as delta-eight thc, #thca , thcv, cbg, #cbn , cbc which have been investigated to have therapeutic value (Izzo et al. 2009).

Although the compounds may have therapeutic effects taken alone (as in HEMP-derived isolate), their combined action when present together in whole plants (actually complete flower) extracts, is GREATER than the sum of their individual effects (up to 6x more potent according to recent studies). This enhanced and synergistic response is known as the #entourageeffect .

The combined action of cannabinoids and other molecules in the plant may present clinical advantages such as lower adverse effects and greater efficacy on the therapeutical management of several conditions, such as #anxiety , #depression , #pain , #inflammation , #cancer and bacterial / fungi #infectiousdiseases

If other forms of healing interest you, beyond masking symptoms with synthetic proprietary mono-molecules, check this link for a more up-to-date text on cannabis and the entourage effect:
leafwell.com/blog/entourage-ef

#healthcare #medical #healthscience #marijuananews #marijuana #weed #naturalist
#cannabismedicinal #herbalism
#solarpunk #chronicillness #regenerativemedicine #pain
#weed #autoinmunedisease #medicalcrisis #herbalmedicine

A vector illustration of a cannabis leaf with, each tip named differently: Terpenes, Flavonoids, THC, CBD and Other cannabinoids. Around it the same text as in the post. Above it the title CANNABIS AND ENTOURAGE EFFECT 1+1=3. Under it a tiny timeline: 1998: First study by the Mechoulam lab cunning an "Entourage effect describing the enhanced action of endocannabinoid 2-AG by other "silent" molecules that are similar in structure. 2011: A comparative study sponsored by GW Pharmaceuticals on the potential analgesic, antiinflammatory and anti-cancer affects of cannabinoids and cannabis extracts mediated by the TRP receptors. 2011: Doctor Ethan Russo proposes a theoretical "entourage effect" between the terpenes naturally present in cannabis that may modify the pharmacological effects of Delta-9 THC.
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JADe (he, him)

"There may be instances where only a single cannabinoid (isolate - as in hemp extract) is needed, but in general, cannabinoids work best together and deliver the entourage effect. Pinene and CBD can mitigate some of THC’s adverse effects on short-term memory. A broad spectrum of cannabinoids is also ideal for treating cancer, as they work synergistically to boost their antitumor properties. Combining cannabinoids and terpenoids ( as in complete spectrum FLOWER) can also improve their usefulness as anti-inflammatories and painkillers."
leafwell.com/blog/entourage-ef

Friends, lets take care of our bodies and minds too (not only our computers and software). Self-care is a form of resistance in these trying times. Synthetic medication is always a double-edged sword.

I'v been helping my family with this ancestral medicine for almost 6 years now. Let me know if you have any doubts on how to best use it for your condition and metabolism. No sales or distribution.

#health #medical #healthscience #marijuananews #marijuana #medicalcannabis #weed
#regenerativemedicine #cbd
#thc #cbn #thca #pain #chronicillness #chronic
#autoinmunedisease #autoinmume #medicalcrisis
#solarpunk #naturalist #herbalmedicine #herbalism

Ilustration on the effect of different THC:CBD ratios. 1. Low THC and high CBD is likely to have no psychotropic effect, but anxiolitic psychoactivity. 2. High THC and low CBD dampens the psychotropic effect and increases how long the analgesic effect lasts. 3. Both in high dose are likely to be psychoactive and sedative with longer lasting effect than THC alone. 4. A low THC and low CBD mix or flower is likely to have an energizing, mild psychoactive effect. 5. A medium dose of both THC and CBD will retain some mild psychoactivity along with potent antiinflammatory effect.
Replied in thread
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JADe (he, him)

@callunavulgaris @donty

I have an 82 year old mother. Health and aging discussions are subrepresented in the Fediverse.

Understand what you are going through. This post might help.

pixelfed.cr/p/JorgeAD/80123188

#pain #chronicillness #chronicpain
#medical #weed #cbn #cbd #weed

PixelfedJADe (@JorgeAD@pixelfed.cr)10x color microphotograph of overripe trichomes inside a cannabis flower. When those tiny glands start to turn brown it means oxidation is taking place and THC is turning into Cannabinol or CBN. After years of helping my octogenarian mother deal with chronic pain from her falls and titanium protesis I realized that CBN does most of the heavy lifting THC is credited for. To read the full story, and science behind it, follow the link to my blog. I have included the full recipe for cannabis cream, 6 years in the making. https://jorge--alban--dobles-blogspot-com.translate.goog/2025/02/mariguanol-para-la-abuela.html?m=1&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es&_x_tr_pto=wapp #medicalcannabis #cannabismedicinal #cannabinoids #weed #marijuana #pain #paintherapy #painmanagement #dolor #thirdage #olderpeople #solarpunk #regenerativemedicine #patients #thca #cbda #thc #cbd #terpenes #hemp #stilllife #science #flowerpower #nature #cbn #naturephotography
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JADe
10x color microphotograph of overripe trichomes inside a cannabis flower.

When those tiny glands start to turn brown it means oxidation is taking place and THC is turning into Cannabinol or CBN.

After years of helping my octogenarian mother deal with chronic pain from her falls and titanium protesis I realized that CBN does most of the heavy lifting THC is credited for.

To read the full story, and science behind it, follow the link to my blog. I have included the full recipe for cannabis cream, 6 years in the making.

https://jorge--alban--dobles-blogspot-com.translate.goog/2025/02/mariguanol-para-la-abuela.html?m=1&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es&_x_tr_pto=wapp

#medicalcannabis #cannabismedicinal
#cannabinoids #weed #marijuana #pain
#paintherapy #painmanagement #dolor
#thirdage #olderpeople #solarpunk #regenerativemedicine #patients #thca #cbda #thc #cbd #terpenes #hemp #stilllife #science
#flowerpower #nature #cbn #naturephotography
10x color microphotogra of overripe trichomesinside a cannabis flower
#naturephotography
Replied in thread
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JADe (he, him)

@Kyol

Hola. Yo hago "marigüanol" para mi madre de 82, que también padece de artrosis. Hace un par de años tuvo una caída y ahora lleva prótesis de titanio en muñeca y tobillo.

Este ungüento de CBN + CBD le ayuda a dormir sin dolor.

El Cannabinol (CBN) es activador de receptores CB2, con mayor presencia en hígado, periferia del cuerpo, sistema inmune, piel y huesos.

El CBD es necesario modulador pero como explica este estudio, el control del dolor (analgesia) es mayor si ambos CBN y CBD están presentes en cantidades parecidas. Cuando domina el CBD el efecto analgésico se reduce.

sciencedirect.com/science/arti

Este ungüento se produce al cocer flor "recreativa" equilibrada 1:1 o al menos de tipo indica, en aceite de oliva o aguacate a 90 C por 60 minutos. Una vez cocida pasas esta mezcla por filtros de papel para café. Ya limpia sin materia vegetal la mezclas con una parte igual de manteca de cacao derretida y calientas de nuevo, agitando constantemente hasta emparejar.

Yo uso 4 gr de flor seca desmenuzada por cada 100 ml de aceite. Los tiempos y temperaturas deben respetarse, pues se basan en la Calculadora de Preservación del Cannabis mezcla, y cambia si en la mezcla domina THCA, THC o CBN, lo que cambia el efecto.

metrology.shinyapps.io/cannabi

Pej el THCA que domina en flor "recreativa" cruda no provoca volazón, pero es ansiolítico, neuroprotector, antiespasmódico, antiemético y desinflamante. Razono todas sus propiedades comprobadas y explico su uso como tisana en mi blog:

jorge-alban-dobles.blogspot.co

El THC que domina en flor ligeramente tostada o descarboxilada, es el único realmente psicotrópico, pero el más analgésico y anticancerígeno de todos.

El CBN de la flor cocida, ideal para el ungüento tópico, además de analgésico, es neuroprotector, anti insomnio, destruye superbacterias y atrae células madre de la médula para reparar fracturas y mejorar densidad ósea.

No venta ni distribución, solo educación sobre el tema.

Grafico de flujo con tres niveles. En el superior los cannabinoides ácidos que dominan en flor cruda como THCA y CBDA con propiedades antiinflamatorias, antiespasmódicas y anticáncer. En el medio tras ser calentados hasta perder un carboxilo OH, el THC con propiedades analgésicas, antibacteriales, anticancerígenas, antiinflamatorias, antiespasmódicas, estimulantes del apetito, antieméticas, broncodilatadoras y neuroprotectoras. Junto a el esta el CBD que requiere el triple de tiempo para descarboxilar pero suma propiedades ansiolíticas, anticonvulsivas, antidepresivas y antipsicóticas y de regulación del sistema inmune. Abajo, tras ser oxidado ( cocido) por una hora a 90°C el CBN que es analgésico, antibacterial, anticonvulsivo, antiinflamatoria y antiinsomnio entre muchas otras.
#medicinalplant#cannabis#thc
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Andy

Does anyone know the specific mechanism by which , and specifically , , , or increase visual acuity?

Best guess is that endogenous tend to regulate prefrontal cortex cAMP similar to norepinephrine and α2 agonists.

So, partial agonists like THC/CBN would have a more obvious role in causing a cascade down endocannabinoid pathways. CBD/CBG are antagonists, which suggests they may have classical reuptake inhibition properties.

Continued thread
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🆘Bill Cole 🇺🇦

I am a beneficiary of such medication.
The available OTC sleep aids that really work leave me groggy for a day.
The prescription sleep aids like Ambien demand 8 hours, which I usually just do not have.
The #Cannabis gummies with #CBN work, with more REM and NREM sleep than I used to get in the ~6 hours I can sleep at night. They may also have attenuated weird dreams another (SNRI) med gave me.

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formuchdeliberation

Nature’s sleep aid: Cannabinol shows promise as a safe sedative – Earth.com…

For decades, cannabis folklore has suggested that aged cannabis makes consumers sleepy via the buildup of CBN, but there was no convincing evidence for this... earth.com #cbn #cbd #thc #cannabis #sleepaid

formuchdeliberation.wordpress.

for much deliberation · Nature’s sleep aid: Cannabinol shows promise as a safe sedative – Earth.com…For decades, cannabis folklore has suggested that aged cannabis makes consumers sleepy via the buildup of CBN, but there was no convincing evidence for this… earth.com #cbn #cbd #thc #cannabi…
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COMMU | Mobilidade na RMSP

✂️ Citação: "Moradora da comunidade, Tatiane Vital diz que outro muro que caiu nesta semana motivou os moradores a registrar a ocorrência: // 'Na terça-feira que caiu um muro, o caminhão bateu ali e caiu o muro. Nós resolvemos ir na polícia fazer um Boletim de Ocorrência. Fomos na polícia ambiental e polícia civil. A polícia falou que um perito vinha até aqui pra fazer um laudo. Ele falou agora pra mim que no prazo de 45 dias saía o laudo, mas ele já disse que existe um risco de desmoronamento'" | 🗒️ Comentário: com a derrota da chapa Boulos-Marta, Ricardo Nunes voltou a ameaçar uma pequena comunidade na Vila Mariana. Claramente, o projeto higienista, herdado do autoritário Paulo #Maluf, foi concebido para eliminar a #favela na base da força. | 🔗 Reportagem da #CBN: cbn.globo.com/sao-paulo/notici

cbnMoradores denunciam rachaduras após a retomada das obras do Túnel Sena Madureira em São PauloO grupo ainda reclama da remoção de duas comunidades e da derrubada de árvores
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