Shutting them down is relatively easy and some forms are possible today: a bioengineered HIV-like retrovirus, regular doses of immune suppression drugs, or (epi)genetic engineering.
However, keeping the immunocompromised population alive is much harder. Even in cases today, we have to keep the immune system going.
@manuelcaeiro @likho While it's definitely theoretically possible to replace the immune system, it seems like a monumental technical challenge. The kind of thing that could take much more than just 50 years, and has a low certainty of success in the near future.
That said, I could imagine a situation where immune suppression is normal, and pretty much everyone is immunocompromised by today's standards, even though their immune systems are still functioning.
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